Charlize Theron is in negotiations to star in and produce Murder Mystery for Endgame Entertainment and director John Madden.

We first reported on this project back in December 2010, when Kevin Macdonald was attached to direct. The comedy is described as an, "affectionate deconstruction" of an Agatha Christie-style whodunit, which centers on an American couple traveling overseas.

James Vanderbilt (Total Recall, The Amazing Spider-Man) wrote the screenplay and is producing alongside Beau Flynn, Tripp Vinson, James D. Stern, and William Shively.

John Madden most recently directed The Best Exotic Marigold Hotel, the surprise indie hit that has taken in over $100 million worldwide so far.