Drew Barrymore is set to direct New Line's romantic comedy How to Be Single, based on the novel by Liz Tuccillo, a former Sex and the City story editor.

Co-produced by Flower Films, How to Be Single centers on a 38-year-old woman living in New York and searching for love. Marc Silverstein and Abby Kohn have penned the adaptation.

New Line and Flower Films also teamed on 2009's He's Just Not That Into You, based on the book by Liz Tuccillo and her husband Greg Behrendt.

No production date has been set.