The story says that the actress is going to play: (spoiler alert)
"A woman who's killed off in the opening sequence, a trademark of the franchise - as a favor to BFF and Scream actress Courteney Cox. The role will be similar to Drew Barrymore's killer part in the first film.
"Scream has always been an important part of Courteney Cox's life, and she wanted Jennifer to be a part of the production," an unidentified source reports.
However, Bloody-Disgusting has confirmed with Dimension Films that the Star Magazine story is not true and Aniston will not be a part of Scream 4.
We'll be sure to keep you posted with any further news on Scream 4 as soon as we have more information.