Academy Award nominee Mark Ruffalo (Marvel's The Avengers, The Kids Are All Right), Matthew Bomer (White Collar, Magic Mike), Taylor Kitsch (Lone Survivor, John Carter), Emmy winner Jim Parsons (The Big Bang Theory) and Academy Award winner Julia Roberts are set to star in HBO Films' The Normal Heart.

Directed by Emmy winner Ryan Murphy (Eat, Pray, Love, Glee) and written by Academy Award nominee Larry Kramer (Women in Love), adapting his groundbreaking Tony Award-winning play of the same name, the drama tells the story of the onset of the HIV-AIDS crisis in New York City in the early 1980s, taking an unflinching look at the nation's sexual politics as gay activists and their allies in the medical community fight to expose the truth about the burgeoning epidemic to a city and nation in denial. The Normal Heart will debut exclusively on HBO in May.

Ruffalo portrays Ned Weeks, who witnesses first-hand a mysterious disease that has begun to claim the lives of many in his gay community and starts to seek answers. Matthew Bomer plays Felix Turner, a reporter who becomes Ned's lover. Taylor Kitsch plays Bruce Niles, a closeted investment banker who becomes a prominent AIDS activist. Jim Parsons plays gay activist Tommy Boatwright, reprising his role from the 2011 Broadway revival. Julia Roberts plays physician Dr. Emma Brookner, a survivor of childhood polio who treats several of the earliest victims of HIV-AIDS.

Alfred Molina plays Ned's older brother, Ben, who is a successful attorney. Joe Mantello plays Mickey Marcus, who is an instrumental member of the Gay Men's Health Crisis. Jonathan Groff plays Craig, Bruce's lover, an early victim of HIV-AIDS. Denis O'Hare portrays Hiram Keebler, Mayor Koch's gay aide. Stephen Spinella plays Sanford, one of Dr. Brookner's first patients. Corey Stoll portrays presidential senior advisor John Bower. Finn Wittrock plays Albert, a male model. B.D. Wong portrays Buzzy, a nurse who works with Dr. Brookner.

In 1981, writer Larry Kramer hosted a gathering of six gay men and their friends to discuss the "gay cancer," and to talk about fundraising for research. This informal meeting in Kramer's home would lead to the formation of Gay Men's Health Crisis (GMHC), one of the first advocacy groups for HIV prevention and care.

Kramer's play debuted at New York's Public Theatre in 1985 and was revived in Los Angeles and London, and off-Broadway. The 2011 Broadway revival garnered five Tony nominations, winning for Best Revival, Best Featured Actor and Best Featured Actress.

The film also stars Alfred Molina (An Education), Tony Award winner Joe Mantello (Law & Order), Jonathan Groff (Looking), Denis O'Hare (True Blood), Stephen Spinella (Milk), Corey Stoll (House of Cards), Finn Wittrock (Unbroken) and B.D. Wong (Oz ).