A large spider from the jungles of South America is accidently transported in a crate with a dead body to America where it mates with a local spider. Soon after, the residents of a small California town disappear as the result of spider bites from the deadly spider offspring. It's up to a couple of doctors with the help of an insect exterminator to annihilate these eight legged freaks before they take over the entire town.
- Frank Marshall.....Director
- Jeff Daniels.....Dr. Ross Jennings
- Harley Jane Kozak.....Molly Jennings
- John Goodman.....Delbert McClintock
- Julian Sands.....Doctor James Atherton
- Stuart Pankin.....Sheriff Lloyd Parsons
- Brian McNamara.....Chris Collins