A rather odd thing has just just occurred in the life of nerdy high school student Peter Parker; after being bitten by a radioactive spider, his body chemistry is mutagenically altered in that he can scale walls and ceilings, and he develops a "spider-sense" that warns him of approaching danger. Adopting the name "Spider-Man", Peter first uses his newfound powers to make money, but after his uncle is murdered at the hands of a criminal Peter failed to stop, he swears to use his powers to fight the evil that killed his uncle.
At the same time, scientist and businessman Norman Osborn, after exposure to an experimental nerve gas, develops an alternate personality himself; the super-strong, psychotic Green Goblin! Peter Parker must now juggle three things in his life; his new job at the local newspaper under a perpetually on-edge employer, his battle against the evil Green Goblin, and his fight to win the affections of beautiful classmate Mary Jane Watson, against none other than his best friend Harry Osborn, son of Norman Osborn! Is this challenge too much for even the amazing Spider-Man to handle?