While The Dilemma comes in second with $17.4 and True Grit falls to third.
Or can The Dilemma laugh it's way to the top of the charts?
Vince Vaughn, Kevin James, Jennifer Connelly, Winona Ryder, Channing Tatum, Queen Latifah and director Ron Howard discuss the new comedy.
We're giving away hats and t-shirts from this Vince Vaughn/Kevin James comedy about a man who finds out his best friend's wife is unfaithful.
Vince Vaughn and Kevin James star in the new Ron Howard comedy about infidelity.
A man discovers that his best friend's wife has been cheating on him in Ron Howard's upcoming comedy.
Get your first look at the upcoming Ron Howard comedy about infidelity.
Vince Vaughn, Kevin James and Winona Ryder star in the relationship comedy.
The actors will star alongside Vince Vaughn in the upcoming comedy.
Take a look at new release dates for such films as Your Highness and The Adjustment Bureau
Starring opposite Kevin James and Vince Vaughn on the Ron Howard comedy.
The actor will star alongside Vince Vaughn in the new comedy.