The Three Stooges finishes in second place with $17.1 million and The Cabin in the Woods takes third place with $14.8 million.
Or can new releases The Three Stooges, The Cabin in the Woods, or Lockout pull off an upset victory?
Will Sasso, Sean Hayes, and Chris Diamantopoulos star in The Farrely Brothers' upcoming comedy.
This fake commercial touts a new wonder drug than can prevent the stooge-like behavior seen in this 20th Century Fox comedy.
Will Sasso, Sean Hayes, and Chris Diamantopoulos star as the title characters in this comedy from The Farrelly Brothers.
The updated rendition of the classic comedy trio features Sean Hayes, Chris Diamantopoulos and Will Sasso as the stooges.
Numbskulls Larry, Curly, and Moe were on hand this past weekend to usher in the Daytona 500 with Jane Lynch and Kate Upton.
Will Sasso, Chris Diamantopoulos, and Sean Hayes are seen alongside the Sports Illustrated swimsuit model in this latest photo.
The actresses will also serve as Grand Marshalls of the Daytona 500, which airs Sunday, February 26 at 1 PM ET on Fox.
Curly, Moe, and Larry return to the big screen this April in the long-awaited Farrelly Brothers comedy.
Sean Hayes, Will Sasso, and Chris Diamantopoulos star as the Stooges in this Farrelly Brothers comedy.
The first official look at Will Sasso, Chris Diamantopoulos, and Sean Hayes as the iconic Moe, Larry, and Curly in The Farrelly Brothers' latest comedy.
The Farrelly Brothers direct Will Sasso, Sean Hayes, and Chris Diamantopoulos in this 20th Century Fox comedy.
The Farrelly Brothers comedy starring Will Sasso, Sean Hayes, and Chris Diamantopoulos as the iconic title characters will hit theaters on April 4, 2012.
The Jersey Shore kids talk about their amazing experience filming with the Farrelly Brothers.
The Hall Pass actress will play the wife of Stephen Collins' character in this Farrelly Brothers' comedy.
The Oscar-winning actress will play Sister Rosemary at the Stooges' orphanage in the Farrelly Brothers comedy.
The Will & Grace alum is spotted on the Atlanta set of The Farrelly Brothers comedy.
Check out the first images of Curly, Moe and Larry as well as Sofia Vergara's character Lydia.
The actor will portray Mac, one of the villains trying to exploit the Stooges in this Farrelly Brothers comedy.