Bridesmaids debuts in second place with a solid $24.5 million while Priest opened in fourth place with $14.5 million.
Fast Five drops to second place with $32.5 million while Jumping the Broom debuts in third place with $13.7 million.
Tyler Perry in drag can't beat the tropical birds of Rio.
Tyler Perry's latest effort is predicted to pull in $30 million, but will it fend off Rio.
Christoph Waltz also offers a look at Francis Lawrence's adaptation of the acclaimed best-selling novel.
Get another inside look at footage of the film from the second full-length trailer for the Francis Lawrence directed drama.
Robert Pattinson and Reese Witherspoon star in this adaptation of Sara Gruen's novel about a man who falls for a circus performer.
Unknown, Source Code, Tower Heist images and more from 2011's release slate are also revealed.
The novel adaptation centers on a veterinarian who falls for a horse trainer.
Fox has now slotted the animated Rio for an April 15 release, while the drama Water for Elephants will bow on April 22.
Reese Witherspoon, Christoph Waltz and Robert Pattinson star in this tale of a young man who falls for a circus performer.
The Oscar winner will direct the German-language film Up and Away.
The Inglourious Basterds star will replace Sean Penn in the film.
The actors would join Reese Witherspoon in Francis Lawrence's film.