Yahoo! has unveiled the trailer for Twentieth Century Fox's live-action, CG-animated Marmaduke, which opens in theaters June 4th, and stars Owen Wilson, Amanda Seyfried, Jeremy Piven, Christopher Mintz-Plasse, Ron Perlman, Judy Greer, Anjelah Johnson, Lee Pace, Steve Coogan, William H. Macy, George Lopez, Kiefer Sutherland, Damon Wayans Jr. and David Walliams. Check out the trailer below!

Marmaduke is based on the Brad Anderson-created newspaper comic strip in 1954 that ran for decades and centered on a mischievous Great Dane who lives with the Winslow family. Owen Wilson voices the mischievous hound. George Lopez, Steve Coogan and Kiefer Sutherland voice other animals.

Tom Dey directs from a script by Vince Di Meglio and Tim Rasmussen.