Warner Bros. has unleashed the official trailer for Darren Aronofsky's The Fountain, starring Hugh Jackman, Rachel Weisz, Ellen Burstyn, Sean Gullette, Sean Patrick Thomas and Donna Murphy.

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The Fountain is an odyssey about one man's thousand-year struggle to save the woman he loves. His epic journey begins in 16th century Spain, where conquistador Tomas Creo (Hugh Jackman) commences his search for the Tree of Life, the legendary entity believed to grant eternal life to those who drink of its sap. As modern-day scientist Tommy Creo, he desperately struggles to find a cure for the cancer that is killing his beloved wife Isabel (Rachel Weisz). Traveling through deep space as a 26th century astronaut, Tom begins to grasp the mysteries of life that have consumed him for more than a century.

The Fountain is in theaters October 13th.