This high-concept action-comedy follows Chuck Bartowski (Zachary Levi), a twentysomething video-game enthusiast whose life is thrown into chaos after his friend, a CIA agent, sends him an e-mail subliminally encoded with the worlds secrets. Suddenly, the fate of mankind lies in Chuck's unlikely hands. Now, instead of working at the Buy More electronics store with his nerdy cohorts, Chuck must confront assassins and international terrorists. Guest stars include Michael Clarke Duncan, John Laroquette, Nicole Richie and former NFL Giant Michael Strahan.
A big, bad mercenary dangles Chuck high from a building. To save his skin, Chuck says he has the cipher, the artificial brain to the new intersect computer. The man says to hand it over. Chuck, though hardly in a position to ask, wants to negotiate. The man yanks him up and asks who he is. Chuck says he works for the CIA, NSA and is the world's most important intelligence asset. Of course the guy doesn't believe him. CIA Agent Sarah Walker and NSA Major Casey burst on the scene and, at gunpoint, tell the thug to let the geek go. He does, but escapes.
In the Buy More parking lot, Chuck's dismayed that his life still includes Buy More, guns and spies. He asks Casey why he's still the only intersect. Casey says the other cipher exploded and killed CIA Director Graham. Chuck's shocked about Graham, but still wants to know how that affects him. Casey tells Chuck he isn't leaving Buy More any time soon. Meanwhile, Lester continues his reign of terror as assistant manager, publicly calling out Jeff and Morgan for their transgressions. Chuck can't believe his life has come to this, but Morgan tells Chuck he has a great future and gets to go home to "that." "That" being Sarah, who walks up to Chuck and kisses him. Not out of affection, but as cover to whisper to him that he's needed for a national security emergency.
Former New York Giants star Michael Strahan guest-stars as the intimidating bully Mitt. Chuck is overcome with jealousy when his nemesis Bryce Larkin, Sarah’s ex-lover and partner, makes an unexpected return. Chuck and Sarah’s growing feelings for each other are tested when their latest mission requires Sarah and Bryce to pose as an extremely affectionate couple. Meanwhile, Morgan faces his own challenge at Buy More when he must deal with a gang of bullies, the Mighty Jocks. Led by Mitt, these bullies are the employees of a neighboring sporting goods store, and they love to take over Buy More's home theater room to play sports video games.
Nicole Richie (The Simple Life) and Ben Savage (Boy Meets World) guest-star. Chuck learns more about Sarah’s past when they run into her old high school nemesis Heather Chandler (guest star Nicole Richie). Sarah’s teenage insecurities come to surface and she tries to avoid Heather at all costs. Chuck, on the other hand, does everything he can to hear more about Sarah’s hidden life. When Heather’s nerdy husband Mark (Ben Savage) turns out to be a key player in a new mission, the agents must attend Sarah’s high school reunion to prevent the sale of potentially dangerous super-bomber plans -- all the action ends with the ultimate cat fight. Meanwhile, Big Mike leaves town for a day and Buy More’s new assistant manager Lester decides to implement a new sales policy.
Tony Hale (Arrested Development) guest-stars. Life in espionage takes its toll on Chuck and everyone is taking notice. Chuck tries to explain his unusual behavior to Ellie and to the quirky Buy More efficiency expert Emmett Milbarge (guest star Tony Hale), but a new assignment only complicates things. After a global terrorist comes searching for Jeff , Chuck is forced to socialize with Jeff in order to find out what role the oddball plays in the mission. Sarah, Casey and Chuck are all shocked when they discover that the fate of the world and the prevention of World War III rest in Jeff’s hands.
Jordana Brewster (The Fast and the Furious) and Tony Hale (Arrested Development) guest-star. Chuck runs into his ex-girlfriend Jill (guest star Jordana Brewster) while on a Nerd Herd call. In an attempt to save face, he lies to the girl who broke his heart and tells her that he is more successful than he really is. When Chuck flashes on Jill’s boss—a research scientist who may have developed a deadly bio-weapon, he, Sarah and Casey must find out if Jill is involved. Meanwhile at the Buy More, Big Mike (nearly chokes to death, which leads company efficiency expert Emmett to implement a mandatory CPR course taught by Devon.
Jordana Brewster (The Fast and the Furious) and Tony Hale (Arrested Development) guest-star. Chuck and Jill (guest star Jordana Brewster) are enjoying the honeymoon stage of their rekindled relationship. The two lovebirds plan a weekend getaway but have to cancel at the last minute when Casey and Sarah inform Chuck that he is needed for an immediate mission to find corrupt agents in the CIA. Jealousy erupts when Jill finally meets Sarah and learns that Chuck and his handler must pose as a couple. Chuck does his best to reassure Jill that his relationship with Sarah is purely business but only finds himself in more trouble when his mission does not go as planned. Meanwhile, corporate efficiency expert Emmett is out to get Chuck and interrogates Morgan to get some dirt on his best friend.
Chuck , Sarah and Casey are shocked to discover that Chuck’s girlfriend Jill (guest star Jordana Brewster) is a Fulcrum agent in search of the Intersect. In the wake of his disbelief, Chuck is asked to use his relationship with Jill to get to an agent called Leader. He willingly agrees to bring down the woman who betrayed him twice. Meanwhile, Devon's parents are coming for Thanksgiving and Ellie is determined to have the perfect Thanksgiving dinner. To make sure everything goes smoothly, she tells Morgan that he cannot come to dinner this year. Without any holiday plans to fall back on, Morgan is recruited by Big Mike to stand guard at the Buy More with Lester and Jeff.
Chuck is still reeling from the discovery that his ex-girlfriend Jill was a Fulcrum agent and goes on a mission to take his mind of off his shock. Casey gets a shock of his own when he finds out that his sensei Ty Bennett (guest star Carl Lumbly), who taught him everything he knows, is now one of the most wanted rogue agents. While on the search for Bennett, it becomes clear that Casey may be too emotionally involved to continue with the mission. Meanwhile, Awesome’s parents Honey (guest star Morgan Fairchild) and Woody (guest star Bruce Boxleitner) make a surprise visit to help Ellie and Awesome plan their wedding. At the Buy More, Emmett reinstates the employee of the month contest, but Morgan, Jeff and Lester have other plans.
Chuck spies on Sarah and sees her on a date with an older man (guest star Gary Cole). Chuck frantically tries to warn Sarah after he has an Intersect flash, but she assures Chuck that she is not in danger and reveals the identity of the mystery man. Meanwhile, Anna wants to move into an apartment with Morgan forcing him to finally act like an adult. Awesome offers to help Morgan pay for the apartment, but a relic from the past causes Morgan to lose focus on his new grown-up responsibilities.
Christmas Eve does not go as planned when an amateur criminal on the run from the police crashes into the Buy More and takes Chuck, Ellie, Awesome and the rest of the Buy More gang hostage. In order to protect Chuck’s cover and the safety of the other hostages, Sarah and Casey secretly go in to the store to remove Chuck, but the mission quickly falls apart when Chuck refuses to leave his friends and family behind.
Chuck and Morgan's friendship is put to a test, when Anna and her new friend find Morgan spying on them.
Chuck, Sarah and Casey go undercover in suburbia and find that the neighbors are plotting much more than the next block party.
Flashback to Tarzana 1992: a 12-year-old Morgan Grimes is knocked to the ground by an irate classmate, Suzy, who's accused him of spying on her in gym class. A cowering Morgan is rescued by Chuck, who tells Morgan to grow up. Flash-forward to the present day: in the Buy More's home theatre room, Morgan presents his latest girl problem to Chuck and Lester and Jeff. Not only has Anna broken up with him, he fears she may now be seeing someone else. He pleads with his buddies to help him spy on her to find out. After outfitting Jeff's van with some amateur spy gear, the gang puts a tail on Anna.
Late at night, suave ultra spy Cole Barker digs a hole in an orange orchard. After unearthing a body bag, Cole grabs the corpse's belt and takes off. Back at Castle, Beckman explains that the grave belonged to Brad White, one of the Fulcrum agents who ran the Intersect test on Chuck. Why was his grave robbed, and what was taken? Beckman instructs Casey and Sarah not to let Chuck out of their sight. Sarah immediately phones Chuck.
Chuck pursues one of Fulcrum's scientists, in hopes of learning how to get the Intersect out of his head.
After a smelly mission where they masqueraded as plumbers, Chuck, Sarah and Casey have gotten the intel Beckman wanted. Which reminds Chuck... he asks Sarah if she's heard from Beckman about Orion, which would replace him as the intercept and give him his life back. She assures him that Beckman knows how important it is to him and to leave it to the army of brilliant spy analysts. Even though Chuck said he would, he's up past 4:00 a.m. conducting his own investigation. His sees his web cam turn on and wonders why
A female agent is sent to evaluate Sarah's performance, when Chuck's feelings for her are revealed. Meanwhile, Morgan, Jeff and Lester are trying to get invited to Captain Awesome's bachelor party.
Chuck's life seems to be coming together, his long-absent father has returned and he landed his dream job. Unfortunately for Chuck, neither turns out to be quite what he expected.
Chuck's father is kidnapped and Chuck finds himself in the need to ask his ex-girlfriend Jill for help. Meanwhile, the Buy More team try to bring down Emmett's corporate evaluation.
When Chuck and Sarah go AWOL to rescue Chuck's father, Steve (recurring guest star SCOTT BAKULA), they discover that spending time together without any surveillance allows for unchartered chemistry. As the two get closer, Casey zeroes in on their hidden location. Meanwhile, Morgan becomes the pariah of the Buy More after mistakenly getting Emmett (recurring guest star TONY HALE) promoted.
Ellie's big day finally arrives and Chuck must save her life and her wedding from being ruined by Ted Roark and Fulcrum.