Joss Whedon's Dollhouse is back for an exciting second season! Caroline (Eliza Dushku) - code name "Echo" - is an "Active," a member of a highly illegal and underground group of individuals who have had their personalities wiped clean so they can be imprinted with any number of new personas. Last season, Former FBI Agent Paul Ballard, determined to solve the mystery of the Dollhouse and find the missing Caroline, accomplished his goal and was convinced (or was it coerced?) to become Echo's handler. Dollhouse continues to revolve around Echo's blossoming self-awareness and her desire to discover her true identity. But with each new engagement, comes a new memory and increased danger inside and outside the Dollhouse.
A few months after Echo was kidnapped by Alpha and he imprinted her with all of her previous personalities at once, she is now sporadically remembering her past imprints.
Echo's latest mission is to wed a wealthy and charismatic British arms dealer tied to one of Agent Ballard's open FBI cases.
Meanwhile, Dr. Saunders struggles with being an Active and makes Topher the target of her aggression. Boyd mixes business with pleasure in a risky venture.
When Echo is imprinted as a mother with a newborn baby for a widower, she takes too strongly to motherhood as a result of Topher's genetic adjustment modifications. She kidnaps a child she believes is her own.
Adelle pays November a visit and Perrin ramps up his investigation into the Rossum Corporation.
Echo is sent on an assignment as a fun-loving, seductive college student. Yet Paul is pulled away from his first assignment as Echo's handler to interrogate Victor, who is imprinted as the psychotic serial killer nephew of a Dollhouse shareholder. When Victor escapes, Topher's attempt to stop him accidentally imprints Echo as the killer.
Sierra's shocking introduction to active life is revealed.
Senator Daniel Perrin is on a mission to expose secrets of the Dollhouse and Echo is sent to put an end to his plan. Adelle realizes that someone is trying to eliminate the LA Dollhouse and is using Perrin to do so. Meanwhile, Paul makes contact with Perrin's surprise witness and attempts to derail the senator's plans.
Echo meets Bennett Halverson in Washington and both of them receive a shock. Adelle must deal with her DC counterpart, Stewart Lipman. Topher recruits Victor, and Senator Perrin finds unexpected help in his quest to reveal the activities of the Rossum Corporation.
Echo is left adrift in the world after her experiences at the DC Dollhouse, and her multiple personalities struggle against each other... and Echo. Meanwhile, Boyd receives a call and Harding makes his move against Adelle.
Alpha returns and goes after Echo's past romantic clients, killing them one by one.
Victor's contract lapses and he goes back out into the real world... but his past life may threaten his future with Sierra.
Echo is deemed too dangerous and is sent into her worst nightmare. Trapped in the Attic, she must escape before the psychological manipulations drive her mad.
Topher races to reconstruct Echo's original personality and memories when Adelle realizes they are the key to adverting a devastating future. Meanwhile, Echo and Bennett's shared past and the identity of the Rossum's Corpration's mysterious leader are revealed.
Sacrifices are made when Echo (Eliza Dushku) leads her crew to Arizona to dismantle the Rossum Corporation’s mainframe.
In the year 2020, Echo and the few surviving Dollhouse staff struggle to restore mankind after the devastating events seen in the first season episode, "Epitaph."