In the final season, each of the boys tries to make it on their own: Vince has a new pet project; Eric is running his own management company; Drama is shooting his animated series; Turtle has started a new business venture; and Ari & Mrs. Ari have split.
Fresh from rehab, Vince (Adrian Grenier) is psyched about a new film idea, but the guys don’t share his excitement. Eric (Kevin Connolly) and Scott (Scott Caan) sign Johnny Galecki to their new management company. Ari (Jeremy Piven) tries desperately to win back Mrs. Ari (Perrey Reeves). Drama (Kevin Dillon) throws Vince a “dry” welcome-home party.
Vince’s movie is re-imagined as a TV film starring Drama. Ari takes Lloyd (Rex Lee) on a recon mission. Turtle (Jerry Ferrara) can’t get Alex on the phone. Eric receives a surprising voicemail from Sloan (Emmanuelle Chriqui). Andrew Dice Clay, Drama’s co-star on “Johnny’s Bananas,” needs representation.
Vince (Adrian Grenier) bumps into old foe Carl Ertz (Kim Coates), who expresses interest in producing the miner movie. Although “Johnny’s Bananas” has yet to air, Andrew Dice Clay convinces Drama (Kevin Dillon) that they should renegotiate their contracts. Lloyd (Rex Lee) sets Ari (Jeremy Piven) up on a date to cheer him up. Turtle (Jerry Ferrara) gets news about his stake in Avion, and about Alex.
After Vince finds himself at a crime scene, the guys go to ingenious lengths to make sure he passes a drug test, while Shauna (Debi Mazar) manages damage control with the press. In the wake of a sour couples’ therapy session, Ari gets back at Mrs. Ari (Perrey Reeves) by taking an old flame to Bobby Flay’s restaurant.
With things not panning out with his new co-star, Drama plots to get Dice back on the show. Eric meets up with Melinda Clarke, Sloan’s ex-stepmother, and the two end up commiserating over their exes. In an effort to repair his image, Vince agrees to a Vanity Fair interview, while Ari has an awkward business meeting with Dana Gordon (Constance Zimmer).
After his interview, Vince tries to make things right with journalist Sophia Lear (Alice Eve). Ari gets a reality check from his lawyer about his divorce. Eric receives an over-the-top gift from Melinda Clarke, and some unsettling news from Johnny Galecki. Turtle meets with his East Coast partners on a new business venture. Drama shows his solidarity.
Vince (Adrian Grenier) continues to woo Sophia (Alice Eve). The DeLucas (Sonny Marinelli, Elizabeth Regen) fall in love with a pricey restaurant space, forcing Turtle (Jerry Ferrara) to pitch his investors for more money. Distraught over Sloan (Emmanuelle Chriqui), Eric (Kevin Connolly) turns to Melinda Clarke (again) and the pair crash Sloan’s date. Ari (Jeremy Piven) makes an emotional connection with the script for Vince and Drama’s (Kevin Dillon) miner movie.
After a first date, Vince pulls out all the stops for Sophia. Ari and Mrs. Ari (Perrey Reeves) take a step forward, and a step back, at therapy. Drama, Turtle and Vince try to convince Sloan to give Eric another chance.