Set in a breathtaking small town in the Rocky Mountains, the emotional center of Everwood is the visceral, often heartbreaking relationship between a father and son. After his wife dies, Dr. Andrew Brown (Treat Williams), a renowned neurosurgeon, moves his teenage son and young daughter from urban New York to the idyllic mountain town of Everwood, Colorado, in order to bond with his family.
After the death of his wife, Dr. Andrew ""Andy"" Brown trades his career as a renowned neurosurgeon for an opportunity to be a better parent and move his two children to Everwood, Colorado.
Andy and Ephram's fragile relationship is further strained when it appears that Andy is once again giving priority to his work instead of his family. Meanwhile, as the town of Everwood celebrates its annual Fall Thaw Festival, Ephram's interest in Amy continues to develop, and Delia gets into trouble at school for questioning her teacher's antiquated rules.
Dr. Brown's neighbor and friend Nina (recurring guest star Stephanie Niznik) is ostracized by the townspeople when they discover that she is a surrogate mother for a woman in her mid-50s.
Dr. Brown and Dr. Abbott must put aside their differences to educate the town of Everwood after several of their teenaged patients are diagnosed with a sexually transmitted disease. To make sensitive matters worse, Dr. Abbott suspects that Bright may have been intimate with one of the patients. Meanwhile, Ephram ignores his romantic feelings in order to comfort Amy.
After a lost deer makes its home in the Browns' backyard, Dr. Brown insists on accompanying Ephram while he helps the animal return to the wilderness. Meanwhile, Ephram finally admits to Amy that he never asked his father to consider operating on her comatose boyfriend. Also, Delia questions the existence of God.
Amy is heartbroken-and Ephram is furious-when Dr. Brown decides against performing a risky operation on Amy's comatose boyfriend. Delia is forbidden from playing with her only friend.
With the help of his friend and surgical partner from New York, Dr. Brian Holderman, Dr. Brown operates on Amy's comatose boyfriend, Colin.
As his wedding anniversary draws near, Dr. Brown loses hope and questions whether he will ever feel like his life is worth living again. Ephram and Amy share their first kiss.
Ephram and Delia's grandparents, Grandpa Jacob Hoffman and Nonny Ruth Hoffman, make an unexpected visit to check on their son-in-law--and they question Dr. Brown's parenting skills.
Delia and her grandmother, Nonny Ruth Hoffman (recurring guest star Doris Belack), host a festive birthday party for a grumpy Edna, who hates this particular day of the year.
Hoping to cheer up Delia, Ephram tries hard to recreate the Thanksgiving traditions of their mother as the Brown family spends its first holiday without her.
When the owner of Everwood's flower shop dies, Dr. Brown discovers that she was growing marijuana in her backyard to help people who were suffering from cancer.
Much to the chagrin of Dr. Abbott, who considers himself Everwood's thespian, Dr. Brown begrudgingly auditions for and is offered the lead role in a local production of "The King and I."
Although conflicted by his feelings for Amy, Ephram finds himself serving as confidante and friend to Amy's formerly comatose boyfriend, Colin, who continues to struggle to reclaim his life.
On a church skiing trip chaperoned by curmudgeonly Dr. Abbott, Amy and Colin share their first kiss since his surgery; Ephram becomes intrigued with Colin's younger sister, Laynie.
When traveling psychologist Dr. Gretchen Trott (recurring guest star Jane Krakowski) comes back to town, Dr. Brown realizes how attracted to her he is.
Dr. Abbott's dementia-plagued, elderly godfather, Judge Marvin Harrison, confesses to a murder that took place 30 years ago--and claims that Dr. Abbott's father was his accomplice.
As the anniversary of his mother's death approaches, Ephram confronts a repressed memory of his father cheating on his mother. The memory causes the rift between father and son to escalate.
Although Amy and Bright are still in denial regarding Colin's recovery, Ephram can't ignore the negative signs any longer after he witnesses Colin losing control.
Ephram feels the pressure of performing his first piano recital in Everwood. Dr. Brown and Dr. Abbott attempt to diagnose a mysterious sleeping disorder that leaves welts on his body.
In a controversial and moving episode, Dr. Brown confronts his deepest convictions while trying to help a local girl, Kate Morris (Kate Mara), who is in big trouble.
After Colin has a seizure, Dr. Brown strongly advises Colin's father, James, to allow him to perform brain surgery on Colin. But Colin's parents resist the dangerous procedure.
As the day of Colin's brain surgery approaches, Dr. Brown travels with Ephram and Delia to New York to consult with his accomplished mentor, Dr. Donald Douglas.