After Frank and Marie have a wonderful time visiting old friends, they deliver the shocking news to the family that they have decided to buy a condo in New Jersey. Ray, Debra, Robert and Amy can barely contain their happiness now that their nagging parents will live 85 minutes away. Marie offers to sell Robert and Amy their house for $26,000, the same price they paid for it, and they happily accept.
Robert's anxiety gets the best of him when Amy puts her personal touch on their newly acquired home. Amy starts by attacking Frank's "odor" with lilac air fresheners, throwing out Marie's salt and pepper shakers and replacing the old dial phone. Meanwhile, Ray and Debra visit Marie and Frank for the third time in two weeks. Ray is called to the condo office to sign an insurance form for Marie and, while there, the head of the facility tells him and Debra that Frank and Marie must move out.
Ray craftily turns what looks to be misfortune, after Debra and Marie fight, into a night of passion by helping Debra channel her emotions into what he terms "angry sex." The next evening, while Ray tells Robert, Gianni and Bernie details of his wild night, an enraged Debra returns after a day of shopping with Amy. Ray excitedly kicks everyone out of his house so he can "tend" to his wife. Marie disrupts the plan as she comes in the house through the kitchen with a cake and wants to apologize to Debra.
Following a PTA meeting, Debra comments on Ray's sloppy attire, and he tells her that he overheard one of the mothers say that she looked trampy. Amy doesn't help matters when she admires Debra for wearing clothes that aren't necessarily age-appropriate. The next day, Robert discusses the situation with Ray and learns that Ray's feelings were hurt and he made up the entire story. A week later, Debra purposely dresses "trampy" and confronts the PTA women face to face.
Debra and Ray are astonished when Ally comes home with an "F" in math on her report card. Ray and Debra set up a meeting with math teacher Mr. Putnam to see what she could do to improve. Ray immediately picks up a "mean vibe" when they enter the classroom and clashes with Debra on how they should handle the situation. Later that evening, Amy tells Debra about a crush that Ally has for a "cute boy" in her math class. The next day, Debra has a follow up discussion with Mr. Putnam to tell him about Ally's distraction, but finds he's insensitive and mean. This leads to a role reversal back at the Barone home, as Ray becomes the responsible adult while Debra is concerned with the "cute boy" in Ally's life.
Rays unwillingness to share parental responsibilities with Debra sparks a conversation about his own childhood. Debra, Amy and Marie convince Ray and Frank to accompany Robert to see his therapist, Dr. Greenberg. Moments after arriving at his office, Ray and Frank coerce Robert to ditch therapy and go to the racetrack instead. For the next five weeks, under the pretense of going to Dr. Greenberg, the boys formulate their psychological breakthroughs while betting on the horses and enjoying each others company. But their fun comes to an end when their wives find out that Dr. Greenberg passed away and the boys have been going to the racetrack.
Debra invites her divorced parents to Thanksgiving dinner. Marie agrees to let Lois stay with her while Warren sleeps in Ray and Debras bed. Ray is traumatized when he goes to his room and walks in on Lois and Warren having sex. The next morning, Debra misinterprets her parents rendezvous as reconciliation.
Wondering why Marie is being extra nice to Robert and Amy, Ray discovers her plan: She wants grandchildren. Robert shares his disbelief with Amy that they are being played by Marie. Together, they confront Marie about her manipulative efforts in getting them to breed (plying them with massage oils, candles, liquor and the music of Barry White).
Amys parents are concerned that Peter is lonely and should start a family. Ray unwillingly goes to Peters to give him some dating advice and encouragement. When that fails, Ray and Debra throw a cocktail party at their home to introduce Peter to eligible women. Horrified that Debra invited Peggy (the cookie lady) because she beat him up, Ray tries to push Peter toward Roberts ex, the lovely Stefania. But Peter only has eyes for Peggy.
Ray frantically rummages through the kitchen drawer so he can show Andy and Gianni a personalized letter from Muhammed Ali. Debra is immediately assumed guilty and denies all blame, but later confesses to Marie that she lied to Ray and accidentally threw the letter out. Marie surprisingly covers for Debra and accepts fault for the letter being lost. For taking the blame, Marie tells Debra that someday shell owe her a favor. A week later, Marie calls in her favor to Debra.
Ray is dumbfounded when he realizes the magnitude of the blunder he made while at a Knicks game with Michael and Geoffreys friend, Chris. Ray commented that the janitors would pick up Chris mess, not knowing that Chris dad George works as a custodian at the kids school. Ray makes matters worse when George comes over to pick Chris up and Ray repeats the entire incident verbatim. Debra presses Ray to apologize immediately, but mayhem ensues as everyone in the Barone family reveals to George different faux pas theyve made in specific situations.
Marie is astounded when Frank puts salt on her homemade lasagna. While Debra and Amy console her, Ray and Robert discover that Frank lost his sense of taste from taking special herb pills for his foot. Ray and Robert reveal to their wives the truth about Franks problem. Ultimately, Marie finds out that Frank was forced to choose between maintaining a physical relationship with Marie or lose his sense of taste.
Ray tells Robert that Amy is a chatterbox because she wouldnt stop talking to him while he was watching a basketball game. Rays comment hurt Amy, but Robert cutting her off while she's talking angers her. The next night, the three Barone couples get together for Amys first annual fondue night, where the family gangs up on Ray to discuss his lack of communication with them.
Ray decides to watch the overtime of a basketball game instead of having sex with Debra. The next day, Debra gives Ray the look that she wants to have sex but later that night Ray surprises her by denying her once again. Debra confronts Ray when she discovers that hes been withholding sex from her in order to shift the power of their relationship.
Robert is shocked when he catches Pat smoking a cigarette, but is thrilled to be part of Pats dirty little secret. Robert continues to seize this opportunity to bond with Pat by taking a drag of a cigarette; when Amy smells smoke on Robert, his family accuses him of being a smoker. Ultimately, the entire family swaps secrets of how they let off steam so they dont blow up on their loved ones.
In the series finale, Ray is admitted to the hospital for minor surgery, but unexpectedly falls into a coma. The family, fearing the worst, experiences a number of heart-warming flashbacks.