The show follows the adventures of lovable oaf Peter Griffin and his hilariously odd family of middle-class New Englanders.
When the power goes out Peter decides to entertain the family with his version of the Star Wars saga starring Chris as a whining Luke Skywalker and Peter as an extra large but heroic Han Solo.
When Peter convinces Brian to move in with his dense girlfriend Jillian, she ends up smothering him, but he keeps her around for the lovin'.
After Bonnie (Jennifer Tilly) tells Joe (Patrick Warburton) that she is tired of being married to a handicapped person, Joe decides to get a leg transplant.
In the 100th episode, Lois and Peter go on a cruise, leaving Stewie and the family behind.
While all of Quahog assumes she's dead, Lois returns from the wilderness and names Stewie as her killer, but he goes on the run.
This is when Lois realize's that Stewie is an evil baby and she knows that she has to kill him. Peter and everyone else in the world are servants to Stewie but Lois is the only one who can stop him.
When a flood hits Quahog, Meg winds up in the hospital in a coma, but she wakes up to a cute med student and they hit it off.
Peter eats so many burgers that he eventually has a stroke.
James Woods returns after being locked in a crate to seek revenge against Peter.
Peter and Lois are having marital difficulties, as Peter would much rather spend time with his friends than with his wife. Brian, who has announced that he won an award for an essay he wrote and was invited to Martha's Vineyard to receive it, offers to take them with him on vacation to ease the anxiety. Peter and Lois agree, and when the three arrive at their fancy hotel, Peter immediately begins enjoying himself. As such, he fails to arrive on time for the party at which Brian receives his award. Brian reads an excerpt from his poem, which is about Lois, and touches her heart. When Peter does arrive, he is completely drunk and consequently chastised by Lois.
The next morning, Lois decides to put the issue with the other night behind her, but agrees to spend the day with Brian as Peter has already made plans for himself. Toward the end of the day, Lois is dismayed to find that Peter is gone yet again, as he has soiled himself from laughing so hard from watching Three's Company so she decides to spend the evening with Brian. As Brian makes preparations, he begins experiencing fantasies of himself kissing Lois and declaring his passion for her. That evening, Brian loses his self-restraint and attempts to make a pass at her aggressively; Lois is greatly troubled by this, so she forces him out of the room.
Brian mulls over the severity of his own actions, even calling himself a rapist, and asks Stewie for help (who mistakenly believes that Brian and Lois actually had sex). Lois remains concerned for both Peter and Brian, and tells Peter about what happened the next morning. Peter confronts Brian at the hotel bar, warning him as lightly as he can to stay away from his wife. Brian says that Peter is too stuck-up to be good enough for Lois; Peter counters by saying Brian has never had a long-term relationship with any woman he has ever been with. Their argument quickly escalates to extreme violence, but Nathan Lane appears and breaks the two up (saying "get off my husband"). Things quickly settle down as Peter and Brian agree to resolve this problem another way. Brian ultimately promises never to let Lois come between their friendship ever again, and they forgive each other. Brian formally apologizes to Lois for his actions and she forgives him as well, though she does admit that sometimes she feels the same way Brian does about her. As the three leave the harbor, they sing "The Spirit of Massachusetts" and the three happily return home as if nothing bad ever happened.
Back at home, since no one else was available, Peter and Lois have decided to hire Herbert to look after Meg, Chris and Stewie while they are away. Herbert makes several sexual remarks to Chris as he always does. Herbert surprises the children when after announcing it is bath day; not for the children, but himself. He is disappointed because Meg bathes him; he wanted to receive a bath from Chris. That night, after Herbert reads Chris "Peter and the Wolf" as a bedtime story, Chris finally asks him, "Are you a pedophile?" (Herbert's answer, if any, is not shown). During the ending credits, the Evil Monkey pops out of the closet expecting Chris, but instead sees Herbert sleeping, and backs into the closet, completely creeped out.
Brian decides to start a relationship with a nice young widowed woman he meets one day. He agrees to perform magic at her son's birthday party just to impress her, only to learn that she already has a boyfriend she never told him about. Feeling he may be losing his chances at love, Brian ultimately decides to meet up with a former flame named Tracy who, once being quite attractive, has since become fat and slovenly. Partially repulsed, Brian decides to leave, but Tracy insists he stay after revealing that she has a son named Dylan and that he is the father.
Dylan proves to be quite the unruly teenager and Brian laments to Peter and Lois about his experiences with him. Despite his objections, they attempt to convince him that he should take responsibility for his son. At this time, Dylan arrives at the Griffins' house, explaining that Tracy dropped him off for Brian to raise. There he begins tearing the house apart (even beating up the Evil Monkey, though Chris has no problem with this) and acts hostile toward everyone, especially Brian, who decides to take control and kick him out. However, after discovering a shared enjoyment of marijuana, the two smoke up and bond. They begin to connect when Brian apologizes for not being there for Dylan which causes both of them to start crying and bonding, and Brian swears to turn Dylan's life in the right direction.
Brian quickly shapes Dylan up to be a fine young man, though he himself begins to act a bit self-righteous. Peter feels very uncomfortable about this, so he decides to convince Tracy to take Dylan back to live with her in the hopes that Brian would go back to normal. Lois supports Peter's position as she, too, has been feeling disturbed that Brian has become a stereotypically overprotective parent right after taking Dylan under his wing. While Brian attempts to justify his behavior, Dylan steps up, saying it is time for him to turn his mother's life around just as Brian had done for him. Brian agrees, and the two part ways.
Yo ho ho! It's a pirate's life for Peter when he gets a pet parrot.