Beautiful, privileged and talented, aspiring heart surgeon Dr. Zoe Hart must take a job as a general practitioner if she wants to get an important fellowship next year. Offered a position by a mysterious southern country doctor, this lifelong New Yorker packs her bags, slips on her stilettos and leaves Manhattan for life on the Gulf Coast. Welcome to BlueBell, Alabama, where no one has ever seen the likes of Dr. Zoe Hart.
Fast-talking New Yorker Zoe Hart (Rachel Bilson) has her life all figured out until she is turned down for a prestigious fellowship she had been certain she would get. Desperate, she decides to finally accept the offer of a kindly stranger, Dr. Harley Wilkes (guest star Nicholas Pryor), whom she met at her medical school graduation, and who had proposed she join his small medical practice in Bluebell, Alabama.
Hoping it might help the residents of Bluebell accept her as one of their own, Zoe Hart (Rachel Bilson) agrees to join Mayor Lavon Hayes (Cress Williams) on his float during the Founder’s Day Parade, but, unfortunately, accidentally crashing the float doesn’t exactly help Zoe win over Lemon Breeland (Jaime King) and the residents of Bluebell. To make matters worse, the town’s golden boy, George Tucker (Scott Porter), informs Zoe that contractually she needs to bring in thirty percent of the business or Dr. Brick Breeland (Tim Matheson) will have the option to buy out her half of the medical practice.
Zoe (Rachel Bilson) is determined to win Bluebell’s gumbo contest and prove to everyone that she is a part of the community, which will hopefully help her land some patients. Lavon (Cress Williams) develops a crush on Zoe and Brick’s (Tim Matheson) new receptionist, Didi (guest star XX), but things get a little messy after Lemon (Jaime King) catches wind of the news. Zoe and Brick find themselves having to work together to perform a life-saving surgery.
As Bluebell is hit by an intense heat wave, Zoe (Rachel Bilson) discovers that the hot weather makes everyone act differently and with a lot less inhibition In fact, it takes all of Zoe’s strength to ignore her heat-induced attraction to Wade (Wilson Bethel) until it gets the best of her. Meanwhile, Lemon (Jaime King) prepares for the arrival of George’s (Scott Porter) family, determined to win them over, but her emotions get the best of her when Lavon (Cress Williams) shows up to the same restaurant with his date, Didi (Nadine Velazquez).
Zoe (Rachel Bilson) discovers something shocking about the local minister (guest star Peter MacKenzie) and his wife (guest star Kerry O’Malley), causing quite a stir among the residents of Bluebell. Lemon (Jaime King) is determined to find the funds to renovate the town’s historic bridge that was destroyed by Hurricane Katrina, but first she is put in the extremely awkward position of having to convince Lavon (Cress Williams) to choose her proposal over so many other worthwhile submissions.
Driving home late one night from a house call, Zoe (Rachel Bilson) accidentally hits a man but can’t find any signs of him when she gets out of her car. Later, she sees the man’s photo hanging in the Rammer Jammer, and George (Scott Porter) has to break the news to her that the man in the picture died over a year ago. Meanwhile, Lemon (Jaime King) and George are ready to buy their dream home until Lavon (Cress Williams) steps in and refuses to authorize the purchase because it is one of Bluebell’s historic properties. Zoe’s mom (guest star JoBeth Williams) shows up in Bluebell hoping to reconcile with her daughter after keeping the identity of Zoe’s real father a secret Zoe’s entire life.
When Nascar’s Brian Vickers (appearing in the episode as himself) has to drop out of hosting Bluebell Junior League’s annual turtle race, Lemon (Jaime King) is reluctantly convinced that the mayor (Cress Williams) is the perfect replacement as her co-host. Zoe (Rachel Bilson) is asked out on a date by a handsome local veterinarian, Dr. Judson Lyons (guest star Wes Brown). Wade (Wilson Bethel) has an unexpected visitor who stirs up all kinds of trouble for him.
Noticing that Zoe (Rachel Bilson) is feeling homesick, Lavon (Cress Williams) suggests that she host his annual pre-game homecoming party to help her feel more connected to Bluebell. Zoe jumps at the opportunity and decides to enlist the help of her friend Gigi (guest star Megan Stevenson) from New York, but as it turns out New York and Bluebell have very different ideas of what makes a good party. Meanwhile, George (Scott Porter) and Wade (Wilson Bethel) hatch a plan to get even with their high school nemesis, Jimmy (guest star Sean Carrigan), but when Lemon (Jaime King) catches wind of their scheme she wants in on the action, too.
While the residents of Bluebell prepare for their annual Planksgiving celebration, Zoe (Rachel Bilson) anxiously counts the days until her return home to New York for Thanksgiving. Unfortunately, getting out of town may be a bit trickier than Zoe anticipated due to the fact that she has to meet her thirty percent quota of patients by midnight or lose her share of the practice to Brick (Tim Matheson). Meanwhile, Lavon (Cress Williams) encourages Wade (Wilson Bethel) to be honest about his feelings for Zoe, and George’s (Scott Porter) father (guest star Eric Pierpoint) offers him an opportunity to join his law firm in Montgomery, which isn’t exactly music to Lemon’s (Jaime King) ears.
Zoe (Rachel Bilson) encourages Rose (guest star McKaley Miller) to enter the annual Miss Cinnamon Cider Pageant even though Lemon’s (Jaime King) younger sister, Magnolia Breeland (guest star Claudia Lee), is a shoo-in to win. Of course, with Zoe coaching Rose and Lemon coaching Magnolia, rivalry takes on a whole new meaning. Meanwhile, George (Scott Porter) and Wade (Wilson Bethel) go on a road trip to pick up a Christmas tree for Bluebell’s town square. Also, in flashbacks, we learn some of the history of Lemon’s relationship with her mother, as well as the details of when Lemon and Lavon (Cress Williams) first realized they had a connection.
When Zoe (Rachel Bilson) goes in search of some family history in Bluebell, she discovers that she is a legacy to the Bluebell Belles. Of course, once Lemon (Jaime King) catches wind of the news, she makes it her sole mission in life to make sure Zoe doesn’t become an official Belle and puts her through a humiliating initiation. With the help of Wade (Wilson Bethel), Lavon (Cress Williams) attempts to jump back into the dating scene, but he finds it difficult because Didi (guest star Nadine Velazquez) is telling everyone that he’s in love with her. Meanwhile, George (Scott Porter) devises a plan to stop a huge chainstore from building near Bluebell and as a result driving business away from the town.
Zoe (Rachel Bilson) is so uncharacteristically happy as of late that it causes her friends to speculate as to the possible reason behind her new attitude. Turns out that Zoe is hiding her new friendship with AnnaBeth (guest star Kaitlyn Black), who doesn’t want Lemon (Jaime King) to find out since Zoe is Lemon’s sworn enemy. Lemon campaigns to become the Belles’ new Memory Matron, but she has to overcome a few obstacles to secure the honored position.
Zoe (Rachel Bilson) decides that it’s too soon in her relationship with Judson (guest star Wes Brown) to go to the annual Sweetie Pie Dance so instead she makes plans to have a sleepover with Rose (McKaley Miller), whose parents are going out of town. George (Scott Porter) misplaces the save the dates for his upcoming wedding which causes major trouble in Lemon (Jaime King) paradise. Lemon wants her father (Tim Matheson) to finally move on from her mother leaving him, so she secretly gets him a date for the dance.
Wade (Wilson Bethel) somehow convinces Lemon (Jaime King) to dress up as Joelle (guest star Courtney Parks) as part of a scheme to convince Joelle’s ex-boyfriend (guest star Ted Welch) that he didn’t actually see Wade and Joelle together. Lavon (Cress Williams) asks Zoe (Rachel Bilson) to help him figure out why Didi (guest star Nadine Velazquez) has been avoiding him, but once Zoe uncovers the shocking reason she isn’t quite sure what to do with the information. George (Scott Porter) comes to Zoe for advice in determining whether there is a medical explanation for the behavior of one of his clients.
Zoe Hart (Rachel Bilson) is thrilled to see snow in Bluebell, but the rest of the town is superstitious that it will bring bad luck. When Lavon’s parents (guest stars Hudson and Pettiford) make a visit to Bluebell, Lavon thinks it’s the perfect opportunity to introduce them to Didi (Nadine Velazquez), but the introduction doesn’t exactly go according to plan. Lemon (Jaime King) and George (Scott Porter) make a big decision about their future.
Much to Brick’s (Tim Matheson) disappointment, George (Scott Porter) is named Bluebell’s Man of the Year. As the town’s mayor, Lavon (Cress Williams) is expected to host a cocktail party in George’s honor, but for obvious reasons this is a difficult situation for Lavon given his history with Lemon (Jaime King). Fortunately for Lavon, Zoe (Rachel Bilson) agrees to step in and help him with the party, but things take a turn for the disastrous when Zoe has to improvise a speech at the gathering. Meanwhile, Magnolia (Claudia Lee) begs Wade (Wilson Bethel) to write a song and perform it with her at the party.
Zoe (Bilson) has conflicted feelings about seeing her estranged father, world-renowned surgeon Ethan Hart (Cole), who has agreed to travel to Bluebell to perform surgery on George’s (Scott Porter) father (guest star Eric Pierpoint) as a favor to Zoe. Fearful of losing George, Lemon (Jaime King) decides she must befriend Zoe in order to prevent her from telling George about Lemon’s affair with Lavon (Cress Williams). Meanwhile, to celebrate the 30th anniversary of the Rammer Jammer, the owner (guest star John Marshall Jones) hosts a signature cocktail contest between Wade (Wilson Bethel) and Shelley (guest star Deborah S. Craig).
Zoe (Rachel Bilson) makes a romantic connection with one of her patients, Jesse (guest star Hartley), and accepts his invitation to lunch. Lemon (Jaime King) agrees to let Magnolia (guest star Claudia Lee) plan her bachelorette party as long as she follows Lemon's strict instructions, but Magnolia has some more "interesting" plans in store for her big sister. Wade (Wilson Bethel) plans a hunting trip for George's (Scott Porter) bachelor party.
After a wild night of partying, Wade (Wilson Bethel) wakes up with a massive hangover, an uninvited houseguest and no memory of what happened the night before. Meanwhile, George (Scott Porter) takes an unplanned roadtrip to New Orleans, and Lemon (Jaime King) finally confesses her troubles to her father, Brick (Tim Matheson).
Wade (Wilson Bethel) signs up for the Bluebell Battle in hopes of winning the five thousand dollar prize, but when he strikes out finding someone to be his race partner, he must swallow his pride and ask Zoe (Rachel Bilson). Meanwhile, Rose (McKaley Miller) is jumping for joy when Frederick Dean (guest star Drew Koles) finally asks her out on a date, and George (Scott Porter) and Lemon (Jaime King) meet with Reverend Mayfair (guest star Peter Mackenzie) to discuss their relationship issues.
Zoe (Rachel Bilson) blames herself when one of her friends faces a health crisis and she didn’t notice the symptoms. With much encouragement from Lavon (Cress Williams), Wade (Wilson Bethel) explores the idea of opening his own bar in Bluebell. Meanwhile, Lemon (Jaime King) plans a romantic night for George (Scott Porter), hoping to get their relationship back on track.
With an impending storm about to hit Bluebell, George (Scott Porter) and Lemon (Jaime King) prepare for their wedding day. Meanwhile, taking shelter from the storm, Zoe (Rachel Bilson) finds herself stranded in a barn with Wade (Wilson Bethel).