House will do whatever it takes to solve a case before it's too late, including sending a member of his team to break into a patient's home in search of clues, to attempting a controversial, trial-and-error form of treatment to see how a patient responds. House's methods may be suspect, but his results are not - he saves lives no one else can.
House is brought in for a consult on a Death Row inmate (guest star LL Cool J) with mysterious symptoms. Cameron feels the hospital's resources would be better served elsewhere, with a young cancer patient. House and Stacy try to establish a good work relationship, especially after he lies to her to secure the transfer of the inmate to the hospital.
A nine-year-old cancer patient is brought before House after she experiences hallucinations. House figures out a way to help her, but it will involve serious risk. The young patient asks Chase if he will kiss her because she's never kissed a boy. They discover that she has a tumor on her heart, but when it is benign, they believe that a clot may be navigating her body.
Cuddy feels responsible when her handyman falls off her roof and starts to show weird signs. House's team amputates one hand to prevent the spread of infection, but then the other starts to show signs and they have to seek out the source before it kills the patient.
A famous doctor gets ill when working in Africa, and is sent to House for treatment. Everyone except House believes that his illness is due to tuberculosis.
A student who just graduated from Princeton experiences severe spasms at graduation party. Meanwhile, House's parents drop by.
A famous cyclist is brought to House's clinic after collapsing during a race. He is surprisingly honest about several illegal medications and techniques he applied to himself, but his sickness is not caused by any of these.
House is confronted by a gay man with AIDS, Kalvin, who demands treatment. The patient coughs blood onto Cameron who then must be checked for the virus herself. Kalvin's father begins to show signs of illness. House makes moves on Stacy using sensitive information he got about her relationship with Mark.
A lawsuit is brought against Chase and House for the death of a mother who came in with stomach pains. A disciplinary committee convenes to determine whether either of them is at fault in the death.
A woman who has a seizure is admitted to the hospital but Cameron wants her to be discharged when they discover she has Munchhausen syndrome; however, House believes she has an underlying condition.
A famed journalist collapses in his magazine company's office. While he acts nonchalantly after getting up, it soon becomes clear from his word-salad-inflected speech that he is suffering from aphasia.
Cameron worries about the potential results of her HIV test. House basks in the afterglow of his kiss with Stacy, but Wilson tries to keep a level head about things. House must dig through the life and lies of a busy housewife to find the true reason why she has shown signs of physical and mental degeneration.
The team struggles to diagnose a teen suffering from spasms when his severe burns make most of their usual diagnostic tests impossible. Meanwhile, House attempts to get revenge on the doctor who turned him in for cheating in medical school.
House treats a teenage supermodel who gets into a catfight on the catwalk and then passes out. When her tox-screen shows heroin, she is treated for addiction. Unfortunately, her symptoms continue after she has weaned off the drugs. Meanwhile, House fights off increasingly bad leg pains.
House tries to treat a man who has a seizure but does not realize it and needs a new heart. When the transplant committee votes "no" for a new heart, House tries to get one from a dead woman whose organs were also rejected by the committee.
When a man cannot breathe after roleplaying with his wife, House must question the motives for the marriage. He also deals with Wilson's presence in his house.
Melinda (guest star Michelle Trachtenberg), a troubled teenage girl who is immuno-compromised as a result of the medications she must take after a heart transplant, has a severe allergic reaction and goes into shock when her boyfriend visits her. Meanwhile, House and Wilson continue to work out the problems in their new living arrangement.
The hospital is hosting an oncology benefit, when a six-year-old boy is brought in exhibiting symptoms identical to those of a patient House had 12 years ago. House is convinced the boy's case is identical, and that he can predict the course of the young patient's illness, which ended in death for the first patient.
A young woman's health becomes a question of ethics. Hannah has been unable to sleep for 10 days. It is not until House discovers she will need a liver transplant that he also uncovers some vital information about her and her partner Max, which might lead to her death. Foreman is accused of plagiarism by Cameron when an article he authors appears remarkably similar to one of hers.
House wants to call a 15-year-old faith-healer's bluff, but when the boy is admitted into the hospital, he touches a cancer patient and causes the cancer to go into remission. After being diagnosed, the boy refuses brain surgery, but when his condition worsens, House and his staff have to make a decision. Meanwhile, Cameron is still sour about Foreman.
House is trying to cure a crooked cop who acts turbulent and laughs uncontrollably, but he and his team are unable to determine the cause. When Foreman starts showing similar symptoms, the situation gets far worse than anybody expected.
The police officer that had the same symptoms as Foreman has died. Fearful of his own death, Foreman contacts his father who rushes to be by his son's side. Meanwhile, House and the rest of the team are still trying to do everything they can to help Foreman.
On his way out the door, a man vomits and decides to stay home from work only to find his wife in the bathtub having a seizure, and their newborn infant drowning.
A 16-year-old Hurricane Katrina victim suffering from horrifying hallucinations is brought to House by his former bandmate, who recently found out the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl's lies so he can diagnose and treat her, he is forced to tell a few lies of his own.
As House and his team are working on the diagnosis of a man with a swollen tongue, the husband of a former patient walks into House's office and shoots him. House continues to treat his patient from his ICU bed with the shooter, who has been shot by hospital security and handcuffed to his bed, as his roommate. When the aftereffects of the shooting begin to impact House, he starts to question his own ability to diagnose properly. As his patient's body deteriorates, House struggles through his self-doubt and must trust his team to find a way to solve the case.