A man with amnesia assists Seattle police with a missing persons case, using his encyclopedic knowledge of the world.
Doe helps the police solve a very bloody murder case while also searching for the mysterious woman who called him "Tommy" from a passing ferry.
While investigating a pair of mutilation murders, Doe asks a psychiatrist to help him recover his lost memories.
A 30-year-old murder case, in which the killer is a dead ringer for Doe, contains some clues to his identity.
Doe finds another man who can't remember who he is, but the man disappears, and the search for him leads Doe into the clutches of a drug-crazed, murderous doctor.
An avant-garde artist who's the primary suspect in an art museum jewel theft turns out to be a friend of Karen's.
When Doe tries to help a young boy find his biological father, it leads to the discovery of a murderer bent on killing, one by one, a group of high-IQ sperm donors.
The mysterious woman with Yellow Teeth leads Doe to yet another possible identity - and an Idaho farm which may or may not be his childhood home.
During a flight to London for a vacation, Doe solves two murders, saves the plane from crashing, clicks with a charming doctor, and saves her from a cold-blooded killer.
The mysterious symbol on Doe's chest is part of the calling card left by a serial killer known as The Mourner.
Serial killer Lenny Pescoe, a.k.a. the Mourner, kidnaps Avery in his latest ploy to involve Doe as his "worthy opponent."
John Doe, a mysterious man who rises from the primordial waters of an isolated island, possessing knowledge of literally everything in the world, yet having no memory of who -- or even what -- he is
As Hayes battles for custody of his children, he and Doe investigate a deranged man who may be kidnapping innocent people to recreate the family he lost in a tragic accident.
Doe suffers intense guilt when he escapes a bombing attempt but allows Karen to be kidnapped.
Doe bristles when the police enlist a self-proclaimed psychic in the search for a serial killer.
As Doe investigates the mysterious asphyxiation death of an astronaut found in a burned-out circle like the one he woke up in, he begins to wonder if he might be an alien.
The police station is taken over by an ex-cop who holds everyone hostage and threatens to contaminate the city with smallpox.
While unraveling a mystery involving a dead computer genius and his ultimate invention, Doe wonders if he might have been part of the genius' experiments.
Being struck by lightning cures Doe's colorblindness, but robs him of his super intelligence.
Doe investigates a secretive hospital conducting psychic "remote vision" experiments.
A mysterious man who knows literally everything in the world - except his own identify - helps the Seattle police force solve "impossible" crimes.