Mike is inspired by their honeymoon trip to Paris to change his life and travel the world, while Molly worries how their family and friends fared at home without them.
When Vince throws his back out during a late night rendezvous with Joyce and she goes AWOL, Mike and Molly get stuck taking care of him. Joyce tells Molly that Vince's health problems brought back memories of the quick deterioration of Molly's father, and that she couldn't bear that kind of pain again. Meanwhile, Mike and Molly struggle to write personalized thank you notes for their wedding gifts.
Molly gets frustrated when all of her wedding photos with Mike turn out terribly. In every photo, he's either slackjawed, eating something, or has his eyes closed. She also gets frustrated with Harry, who's initial edit of her wedding video featured a lot of Victoria's cleavage, Mike sneaking food, and terrible voiceover. Meanwhile, Carl gets jealous and overprotective when Christina's ex-husband, James, comes back into the picture. His fears turn out to be founded, however, when Christina tells him she wants to give James another chance for their son.
Mike and Molly decide the time is right for them to start trying for a baby. Meanwhile, Carl gets upset when he learns that Molly is still spending time with Christina after their breakup.
Mike is forced to set up his mom with his boss, despite his many reservations.
With the house feeling too cramped and crowded, Molly plans a family yard sale. Meanwhile, Mike and the guys take Carl on a fishing trip to help him forget his breakup with Christina.
When Mike gets sick for Thanksgiving, Molly is excited that she doesn't have to cook - until Vince invites his brother to town for a homemade Thanksgiving meal.
When Mike gets nervous after Molly doesn't get pregnant following weeks of trying, he turns to Carl and Samuel for advice.
Molly encourages Mike to go after a detective position, but the stress of taking the qualification exam takes a big toll on their relationship.
Even while portraying Santa, Mike cannot contain his frustrations over Molly's Christmas spending and warns unsuspecting children about the dangers of maxing out credit cards to buy toys. Later, while Molly's family enjoys holiday festivities at home - complete with Christmas carols on Victoria's new karaoke machine - Mike and Molly get roped into spending Christmas Eve at church with Mike's mother and boss.
In an effort to boost their chances of getting pregnant, Molly encourages Mike to join her in giving up caffeine and eating healthier, causing them both to have major withdrawals.
Mike prepares to spoil Molly for her birthday, but his plans go awry after he eats psychedelic gelato made by Victoria's friend Tom.
Mike begins transforming the basement into a living area for him and Molly to live in, but the construction work is more than he or his eyebrows can handle. Meanwhile, Carl invites Samuel to live with him.
Mike and Molly encourage Harry to take Victoria on a date for Valentine's Day, and everyone is shocked when she accepts. Meanwhile, Carl convinces Samuel that they will be able to meet women at the laundromat during the holiday.
Mike studies male fertility and visits a clinic to ensure that his swimmers are up to the task of starting a family with Molly. Meanwhile, Vince gets a new job selling vacuum cleaners door-to-door.
Molly enjoys a shopping spree at the mall after Mike storms off over a disagreement.
Carl and Samuel host a St. Patrick's Day party in hopes of meeting women. Meanwhile, Molly reveals juicy secrets from her previous St. Patrick's Day excursions to Mike.
Molly joins her sister on a spring break road trip to party with Victoria's friends from junior college. Meanwhile, Mike pulls strings with his boss to get special overtime assignments in hopes of making extra money.
Mike's birthday wish is to have his wife and mother get along, but Molly and Peggy butt heads more than ever as they try to plan his birthday party together. Meanwhile, Samuel and Carl compete for the same woman.
After learning that Joyce gave up her artistic talents when she became a mother, Molly decides that she and Mike need to pursue new hobbies before becoming parents, so they take up roller skating.
Mike goes on a junk food binge to cope with missing Molly while she is out of town for a teacher's conference. Meanwhile, Carl contemplates leaving Chicago after learning heartbreaking news from James.
Molly is so focused on directing a school recital that she doesn't realize a fellow teacher is hitting on her. Meanwhile, Vince convinces Mike to join him in an unusual money-making scheme.
Mike and Carl get stuck working at the Renaissance Faire after their boss, Patrick, gets dumped by Mike's mother. Later, as a tornado descends on Chicago, Mike and Molly each confess important news to each other.