Finding themselves in an accident involving Joe Shannon, a pint-sized jumble of bad temper and suspicion, they discover he is dying of cancer but doesn't know it. First they befriend him out of sympathy, but gradually they become genuinely fond of him.
Red Walker, a gambler, entrusts Chessie, his bratty 14-year-old daughter, to Sonny and Will.
Driving through the farm country of eastern Oregon, Will and Sonny meet a man pushing his wife down the road in a wheelchair
Will and Sonny deliver a generator to Shaniko, Oregon, and encounter a single mother and her autistic son.
Will takes a shortcut through the country, but finds fresh skid marks leading off the road to a bullet-riddled car. He and Sonny then learn why the car is there: a modern-day Bonnie & Clyde, plus one.
Will and Sonny help move a low-budget traveling rodeo
Will and Sonny deliver pipe casings to an Idaho wildcat oil well driller, and he hires them to be in charge of oil transportation before the well comes in.
Will, Sonny, and fellow trucker Ike run afoul of a small-town police officer and his speed trap, and they get involved in a series of "touch" football games that turn out having higher stakes, than expected.
Will and Sonny haul auctioned farm equipment for the Hoots, an old-country farming colony, and get involved in a dispute that ensues among them and the surrounding farmers.
Will talks Sonny into hauling timber with Will's Vietnam War buddy in Hood River, Oregon.
Will wins so much money in Las Vegas that he considers buying his own truck and going it alone.
While in a cafe in Las Vegas, Sonny moans to Will about how depressing it is to spend Christmas on the road. So they head for Phoenix for dinner with Sonny's uncle, but end up with Sonny's ex-wife instead.
Sonny's ex-wife has him looking for lost jewelry from an ex-boyfriend.
Will and Sonny deliver two trucks to an eccentric old lady who has an antique Benz that she restored herself. The next day she accuses them of stealing it.
Sonny accepts a racing dog from a freight broker as payment for a debt after Sonny's rig is impounded for a late loan payment.
While avoiding a road construction site, Will and Sonny are trapped by a landslide, along with six other people: a runaway and her boyfriend, an alcoholic trumpeter and his estranged med-student son, and a man and his wife towing their RV.
An insurance investigator is out to jail Sonny and Will for insurance fraud.
A gift case of tomatoes to cafe-owner Janey (guest Gloria DeHaven) from Sonny and Will gets them into trouble when the contents are discovered to contain live ammunition.
In San Diego after making a delivery at the Navy docks, Sonny runs into his old Navy buddy, who enlists Sonny and Will in a chase to catch his truckin' sweetie.
After delivering a load of fabric to a San Diego clothing manufacturer, Will and Sonny are drawn into a ransom delivery after Sonny's friend, the company's VP, is kidnapped.
In San Francisco, Will and Sonny get caught between a trucker pal and his wife Abby . . . and his other wife Betsy.
Sonny assists a woman, Nina, when her car breaks down, loading her car into the trailer and taking it to a repair shop. Sparks fly between them, and they make plans to marry.