Rob Morrow stars as FBI agent Don Eppes, who recruits his mathematical genius brother, Charlie (David Krumholtz), to help the Bureau solve a wide range of challenging crimes in Los Angeles. From two very different perspectives, the brothers take on the most confounding criminal cases, aided by Don's partner, Terry Lake (Sabrina Lloyd), and new FBI recruit David Sinclair (Alimi Ballard).
As Don races to capture a serial rapist who has begun to murder his victims, Charlie uses a mathematical equation to identify the killer's point of origin.
After a series of bank robberies, Don recruits Charlie to help chart the next robbery location, only to overlook the thieves' true motive.
Don relies on Charlie's mathematical insight to help stop a virus that has been killing innocent people in Los Angeles.
Charlie convinces Don to investigate a student's suicide in order to make sure that it was not murder.
Don needs Charlie's help to find out why the daughter of a mathematician is kidnapped.
While investigating a deadly freight train accident, Don and Charlie discover a shocking culprit who is on a mission to diminish public confidence in the railroad system.
After two teens are found murdered, the investigation leads Don and his team to uncover a dangerous counterfeit money ring.
When new information on an old case comes to light, Don thinks he may have sent the wrong person to jail.
Don and his team must stop a sniper who goes on a killing spree in Los Angeles.
Don must find the hijackers of a truck carrying nuclear waste before they detonate a dirty bomb in Los Angeles.
When Don and his FBI team are called in to solve the murder of a computer researcher, they are surprised by what they find.
When a UFO is spotted dangerously close to Los Angeles, Don recruits Charlie to help locate the mysterious aircraft's point of origin and is surprised when it turns into a murder investigation.
Don must find two violent felons who escape after their prison bus is in a car accident.