Numb3rs is a drama about an FBI agent who recruits his mathematical-genius brother to help the Bureau solve a wide range of challenging crimes in Los Angeles. As a seasoned investigator, Don deals in hard facts and evidence, whereas Charlie, a math professor at a California university, functions in a world of mathematical probability and equations.
Don uses Charlie and Megan's expertise when the FBI is called to the scene of a federal judge's wife's murder.
Don and his team must find who is responsible for kidnapping the family of a jewelry store owner before they are killed.
When an alleged stalker breaks into a famous pop singer's house, Don and his team are brought in to lead the investigation. Using the fan letters she received as evidence, Don turns to Charlie, who uses Forensic Information System for Handwriting and discovers that there are two senders, one of them a copycat.
Don and Megan are called to a murder scene when the CFO of a powerful energy company, who was about to testify against fellow executives for stock fraud, is found dead at home with the only witness being her 11-year-old son.
Along with David Sinclair and new FBI Agent Colby Granger, Don discovers a secret code during a raid and enlists Charlie's help to crack it. Using an elaborate game theory model called "hide and seek," Charlie discovers that it is a plan for the assassination of a Columbian exile living in Los Angeles. Charlie and Megan combine their expertise and work closely together to try to prevent the murder from taking place.
Don and his agents must uncover who interfered with a counter-terrorism exercise before deadly results occur.
When a father is killed in a home robbery, Don and his team investigate the connection between several recent robberies in the upscale community.
A routine drug bust unveils a sensitive issue that Charlie takes to heart.
A former chemist of a large pharmaceutical company is discovered to be tampering with medication, and Don and Megan must track him down.
The murder of a researcher leads the FBI to investigate a killer and a human skull.
Don and his team must find the serial arsonist responsible for an innocent man's death.
When a fellow FBI agent working undercover is killed in a gang retaliation, Don and his team must investigate.
The murder of a young student at a card club leads the FBI to uncover a deadly card-counting scheme.
The agents must stop an organ trafficking ring when they discover a young immigrant girl died while selling one of her kidneys.
A Cal Sci science student becomes the suspect when an expensive piece of equipment is stolen from the school's DNA lab.
An anti-war bombing that kills an innocent man becomes personal when the investigation reveals surprising information about Alan's past.
When a psychic leads authorities to a deadly crime scene, Charlie sets out to prove it is just a fluke.
The FBI investigates the murder of a female Iraqi activist that happened on U.S. soil.
Don and his team investigate a school shooting only to be surprised by one of the suspects.
Don takes a deeper look at his life after he investigates the circumstances surrounding an ex-girlfriend's death
When an assailant storms the FBI office with a gun, Charlie gets caught in the crossfire between the suspect and the FBI agents.
Don and his family are in danger when they become the targets of the suspects Don and the team are investigating.
Don enlists Charlie's help when the bodies of five young Asian girls found washed up are suspected of being infected with the Avian influenza virus.
Don and his team must stop a suspected serial killer who drugs and kills young women.