Season 2 finds Sam wrestling with the recent discovery that he may be the son of the Devil. But Sam quickly learns that getting groomed to take over the "family business" comes with a whole new litany of headaches. Sam finds he's not the Devil's only son and that one in particular is hell-bent on taking Sam's place at the Devil's side.
Sam is given a cattle prod to capture a group of demons, but discovers that one of them has an immunity to it, and claims to have found a way to get free of the Devil.
Sam finds it hard to concentrate on his new assignment because of his fascination with how Alan broke out of his deal with the Devil. However, Alan disappears when the two of them are attacked by demons. Meanwhile, a demon becomes infatuated with Ben.
Sam must capture a former boxer by using boxing gloves as a vessel. Meanwhile, Andi is awarded a promotion at the Work Bench.
Ben thinks Nina is disgusted by his human form.
Sam, Sock, and Ben turn to Tony for help when an escaped soul leaves her baby behind. Morgan lets slip to Andi that Sam is really the Devil's son.
Sam is sent on a road trip to catch a soul, and he takes the gang along. When he gets to the town, however, he finds that a tentacled beast has taken over.
Sam is forced to once again take Morgan on a soul catch, but Morgan takes off, leaving Sam to once again do all the work. Meanwhile, Nina offers to take Ben flying, and Sam tries to make up with Andi.
Sam continues his quest to find Alan, who he believes can help him get out of his contract with the Devil.
Sam is sent to the home of the Devil's lover Sally so that she can teach him more of the "family business." She initially refuses, but realizing she can possibly help him out of his contract, Sam asks her to teach him anyways.
Since Ben (Rick Gonzalez) and Sock (Tyler Labine) burned down her lair, Nina (Jenny Wade) moves in with the guys. A remorseful Morgan (Armie Hammer) shows up without a place to stay, so Sam also invites him to live at the house but he turns into a horrible houseguest. Morgan not only flirts with Nina, but also puts Sam in a precarious position. Meanwhile, when Andi (Missy Peregrym) feels left out, so she lets Sock throw a bachelor party at the Work Bench, but things go horribly awry.
Sam, Sock, and Ben go after their old high school teacher, Mr. Sprong, assuming he is the current soul they are trying to catch. The only problem? Mr. Sprong is still alive, and none too happy when the boys take him hostage to try to convince him not to press charges.
Sam ends up working for a company run by the Devil that handles the corruption of souls. However, when Mr. Oliver contacts Sam from Hell and tells him he has the information he needs to break his contract with the Devil, the gang decides to use the company's Hell portal to get Nina through to obtain the information. Meanwhile, Sock tries to date a demon who has the ability to be anything he desires.
When Nina returns from Hell with the information Sam needs, he challenges the Devil to the game he's best at. However, when it comes to a draw, Andi is forced to make the ultimate sacrifice.