Angie Harmon (Law & Order) and Sasha Alexander (NCIS) return for season two of the hit series as Boston's top crime-solving duo, Detective Jane Rizzoli and Dr. Maura Isles. Complete opposites, the two women share an offbeat chemistry and strong working relationship. As the second season opens, Jane and Frankie (Jordan Bridges) are recovering from bullets they took during a siege at the police station.
After taking a bullet in the Season Finale during a siege of the precinct, Jane Rizzoli is honored as a hero at a public event. The celebration is short-lived, however, when disaster strikes. The ensuing case reunites Jane with an old high-school flame, Sgt. Major Casey Jones (guest star Chris Vance), who may be just the person she needs to heal her emotional scars.
Jane and Maura’s relaxing day at an outdoor spa is anything but when they discover the murder of a pregnant woman serving as a surrogate mother. Soon the hunt is on to find the baby’s biological parents.
Shortly after sailors invade the streets of Boston for Fleet Week, a young woman is found dead. Frost's father (guest star Ernie Hudson – Oz, Ghostbusters), a Navy Admiral, comes to town, causing tension with his son. And, Maura goes on a date with Angela's mechanic (guest star Matthew Del Negro – United States of Tara, Parenthood).
When the daughter of a police officer is kidnapped in front of her younger brother, Jane and the team race to find the girl, fearing her abduction is connected to another case in which a young girl turned up dead only hours earlier.
Jane and Maura investigate after the coach of the Boston Pilgrims baseball team is found dead in the locker room. The death comes as a star player and the team owners battle for control of the team. Meanwhile, Jane’s brother Tommy (guest star Colin Egglesfield – Something Borrowed, Melrose Place) returns home after being released from jail.
A Revolutionary War re-enactment becomes the scene of a real killing when a soldier turns up dead. Maura’s extensive knowledge of American history becomes important as she and Jane try to solve the case. And Maura’s brilliant mother, Constance Isles (guest star Jacqueline Bisset – nip/tuck, Joan of Arc), comes to Boston for an art exhibit.
Jane and the team investigate what appears to be a modern-day witch hunt in Salem. Meanwhile, Frankie's old girlfriend returns to town with a surprise, and Jane has no problem speaking her mind about the situation.
Jane and Maura delve into a family's background when a man is killed in what appears to be a mugging gone wrong. Meanwhile, a romantic and mysterious figure from Maura's past shows up, causing a rift when Jane suspects Maura is hiding something.
When a young, female dockworker is found dead, the team discovers that the dock has mob connections that may lead to Maura's biological father (guest star John Doman - The Wire). Jane tries to evade sensitivity training. And Maura starts spending time with Jane’s brother Tommy (guest star Colin Egglesfield - Melrose Place), much to Jane's dismay.
When a young man is killed in a jail bathroom right on the eve of his release, Jane and Maura get a nasty surprise when serial killer Charles Hoyt (guest star Michael Massee - FlashForward) claims to have clues about the murder. Meanwhile, after months of preparation, Frankie Jr. is ready to take the detective's exam.
When a community activist is gunned down, one brave witness comes forward to testify against a well-known gang member who is thought to have murdered 15 people. While the detectives work diligently to put him away, television host Bill O'Reilly comes to town for a book signing and criticizes the police department on-air. Roselyn Sanchez guest-stars as the gorgeous-and-driven Assistant District Attorney Valerie Hudson.
Boston Homicide teams up with the FBI after a bank manager is shot during a robbery. Jane's brother Tommy (guest star Colin Egglesfield) may be facing more trouble just as his relationship with Maura begins to grow. Tessa Thompson guest-stars as by-the-book FBI Agent Anna Farrell, who has a complicated history with Detective Frost.
Jane attends her high school reunion and brings Maura along for the ride, but the fun is cut short when one of her old classmates turns up dead on the football field. Jane must focus on the past when she realizes everyone in her class is a potential suspect. Meanwhile, Korsak gets a visit from ex-wife Melody Patterson (guest star Lolita Davidovich), who hopes he'll invest in her new business. Chris Vance returns as Sgt. Major Charles "Casey" Jones, an old flame of Jane's, and Matthew Del Negro guest-stars as Angela's car mechanic, Giovanni, who once had eyes for Maura.
The world of competitive dance turns deadly when the mother of a star performer is stabbed to death at a competition. Jane and the team search for clues, but they soon realize something is off about the woman's history. Korsak has his hands full when his stepson is accused of shooting a cop. Guest star Lolita Davidovich returns as Korsak's ex-wife Melody.
When a warehouse fire kills a firefighter, Jane and Maura must investigate whether it was arson or an accident. But the investigation hits a snag when a hit-and-run leaves someone in the hospital. Guest star Billy Burke returns as FBI Agent Gabriel Dean, who hopes to rekindle his relationship with Jane. And guest star Jacqueline Bissett reprises her role as Maura's mother, Constance Isles.