The thrilling and terrifying journey of the Winchester brothers continues as SUPERNATURAL enters its seventh season. Sam (Jared Padalecki) and Dean (Jensen Ackles) have spent their lives on the road, battling every kind of supernatural threat. Over the years, after dozens of bloody adventures, they finally closed in on their dark destiny: Sam and Dean, with the help of their friends, father-figure Bobby and fallen angel Castiel, managed to avert the Apocalypse and defeat Fate itself - but at a terrible price.
Castiel (Misha Collins) doesn’t kill Sam (Jared Padalecki), Dean (Jensen Ackles) and Bobby (Jim Beaver) but warns them not to interfere in his business. Assuming his new role as God, Castiel sets out to right some of the wrongs in the world. Dean decides they should bind Death (guest star Julian Richings) and order him to stop Castiel, but the former angel is one step ahead of them, leaving Dean to face a very angry Death. Meanwhile, Sam struggles to deal with the broken wall in his head.
While Castiel continues to struggle with the burdens that come with his new-fangled absolute power, the broken psychological wall in Sam's mind causes him to have hallucinations, flashbacks from Hell, and difficulty discerning what's real and what's not. Bobby worries that Dean is beginning to stumble under the weight of fighting Castiel and keeping an eye on Sam.
Dean (Jensen Ackles) is furious after Sam (Jared Padalecki) disappears to follow a lead on a case with clues that are identical to a case Sam solved as a kid. The demon turns out to be Amy (guest star Jewel Staite), who has been killing low-life thugs and taking their brains for dinner – the same demon Sam found as a kid.
Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate a string of gruesome murders and discover the Egyptian god Osiris (guest star Faran Tahir) is behind the deaths. The vengeful god is putting people on trial for their past mistakes and killing them if found guilty. Osiris hones in on Dean’s guilt and decides he’s the next to stand trial. Sam steps in as Dean’s lawyer, but both brothers are unprepared when Osiris calls an unexpected witness – Jo (guest star Alona Tal).
Sam (Jared Padalecki) and Dean (Jensen Ackles) meet Maggie Stark (guest star Charisma Carpenter), a witch who has unleashed her wrath on a small town, resulting in numerous deaths. Sam and Dean track down her husband, Donald (guest star James Marsters), to see if he can help. Donald tells the brothers that Maggie is mad at him for having an affair and is taking it out on the townspeople.
Sam (Jared Padalecki) and Dean (Jensen Ackles) are once again on the FBI’s “Most Wanted” list when two Leviathans clone the brothers and go on a killing spree. The subject of a nationwide manhunt, Sam and Dean need to drop off the grid so Bobby (Jim Beaver) sends them to Frank Deveraux (guest star Kevin R. McNally), a quirky surveillance expert, for help. Meanwhile, Bobby continues to search for a way to kill the Levianthans, or at least slow them down, so the real Winchesters can stop their evil doppelgangers.
Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate the gruesome murders of resident mediums in Lily Dale, the most “psychic” town in America. They discover that an angry spirit is killing off the psychics one by one, but in a town full of people who claim to be summoning spirits, they have a little trouble identifying the medium controlling the ghost.
While on a hunt, Sam (Jared Padalecki) runs into someone from his past and a confrontation ensues. Meanwhile, Dean reluctantly teams up with a quirky, laid-back hunter named Garth (guest star DJ Qualls), when he finds himself in a situation that he just cannot explain.
Sam (Jared Padalecki), Dean (Jensen Ackles) and Bobby (Jim Beaver) become actual hunters, in the true sense of the word, when they set up camp in a New Jersey state park to track a creature that has been attacking people in the woods. The townsfolk claim it is the real Jersey Devil. Meanwhile, Dean is beyond thrilled to find a Biggerson’s restaurant in town, but is devastated when he discovers the restaurant’s special sandwich seems to be making people crazy.
As Sam (Jared Padalecki) and Dean (Jensen Ackles) race the clock on a high-stakes mission, Bobby (Jim Beaver) seeks the help of an unlikely old friend to solve one of the most personal cases of his life.
Still reeling after what happened to Bobby, Dean becomes dangerously obsessed over finding a way to take down Dick Roman (guest star James Patrick Stuart). Meanwhile, Sam decides to help a teenage girl (guest star Madison Mclaughlin) look for her father (guest star Ian Tracey), a hunter who has gone missing. Sam traces his last steps to a truck stop where the help (guest star Meghan Ory) turns out not to be so friendly.
Sam and Dean tangle with the God of Time (guest star Jason Dohring), who sends Dean back to 1944, where he is immediately arrested by none other than the one and only Eliot Ness (guest star Nicholas Lea). While trying to figure out how to retrieve his brother, Sam is surprised by the reappearance of an old friend.
Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate a case where the victims’ hands and feet have been severed and each have been branded with a strange symbol. While Sam does some research at a local university, Dean heads to one of his favorite places to investigate – the town bar. Dean strikes up a conversation with a local named Lydia (guest star Sara Canning, “The Vampire Diaries”), and the two go back to her place. Sam discovers the symbol on the bodies is a sign of Amazon warriors.
Sam (Jared Padalecki) is forced to confront a childhood fear when a case takes him and Dean (Jensen Ackles) to Kansas to investigate Plucky Pennywhistle’s Magical Menagerie, a local pizza chain that hosts children’s birthday parties. Sam and Dean discover that the victims’ children had recently been to the restaurant and drawn a picture of their worst fear, which then came to life to kill their parent. While Dean confronts the man behind the magic, Sam is left to deal with some very angry clowns.
Four years ago, Sam (Jared Padalecki) and Dean (Jensen Ackles) helped a woman named Nora (guest star Nicole Oliver) exorcise a demon that was systematically killing women in a small town. They managed to save the postal worker, Jeffrey (guest star Russell Sams), while vanquishing the demon but now it seems the black-eyed monster has reared his ugly head and returned for a second helping. The brothers visit Jeffrey, who has been locked in a psych ward since the incident, to see if he can remember any of the demon's plans while he was possessed.
After a ballerina is found dead from dancing herself to death, Sam and Dean look into the case and discover the ballet slippers she wore were cursed. When Dean accidentally touches the shoes, the power of the curse starts to take hold of him.
Misha Collins returns! Lucifer drives Sam to the breaking point... and Sam ends up in a mental hospital. Desperate to save his brother, Dean calls every hunter he knows for help. One of the hunters gives him the name of a healer who turns out to have a very familiar face (guest star MISHA COLLINS).
Dean is surprised when he gets a call from Garth (guest star DJ QUALLS) asking for the Winchesters' help on a case. Sam and Dean discover they are battling a Shojo - a Japanese creature sent to seek revenge on enemies. The worst part about fighting a Shojo? You can only see it when you're drunk!
Sam (Jared Padalecki) and Dean (Jensen Ackles) get a call from Annie Hawkins (guest star Jamie Luner), an old hunter friend, asking for help on a case. When they arrive in town, they find out Annie has disappeared. They trace her last whereabouts to an old abandoned house that is haunted by a powerful ghost.
Dick Roman (James Patrick Stuart) acquires Frank's hard drive that contains sensitive information about the Winchesters and gives it to an unsuspecting brilliant hacker named Charlie (guest star Day) telling her she has 48 hours to crack the firewall or she is fired. Sam (Jared Padalecki) and Dean (Jensen Ackles) are tipped off that Dick has the hard drive and race to get to Charlie before she breaks the code. Meanwhile, Bobby (Jim Beaver) tries to help the brothers, but his rage towards Dick for killing him starts to get in the way.
Meg (guest star Rachel Miner) calls Dean (Jensen Ackles) and Sam (Jared Padalecki) and tells them Castiel (guest star Misha Collins) is awake and talking. Meanwhile, a teenager named Kevin (guest star Osric Chau) gets hit by a bolt of lightening and is turned into a reluctant prophet. Sam and Dean believe Kevin holds the key to defeating the Leviathans but must fight off two Archangels who want him for their own purposes.
In order to defeat Dick Roman (guest star James Patrick Stuart) and the Leviathans, Sam (Jared Padalecki) and Dean (Jensen Ackles) must locate three key items. Castiel (Misha Collins) helps with one but for the last objects, the Winchesters must face two of their strongest opponents an Alpha (guest star Rick Worthy) and Crowley (guest star Mark Sheppard). Meanwhile, Bobby (guest star Jim Beaver) tries out a new ghost trick that ends up being very dangerous.
Dean (Jensen Ackles) and Sam (Jared Padalecki) prepare for battle with Dick Roman (guest star James Patrick Stuart). Dick's in the final phase of his plan and the Winchesters must team up with Castiel (guest star Misha Collins), Bobby (guest star Jim Beaver), Meg (guest star Rachel Miner) and Kevin (guest star Osric Chau), the prophet, to stop him. However, Dick is one of the smartest enemies they've ever faced so it's a mind game to see who can keep the upper hand.