Laura Linney stars as Cathy, a reserved suburban wife and mother whose recent cancer diagnosis forces her to shake up her life and find hope, humor and the light side of a dark situation, while managing her immature but well-meaning husband, played by Oliver Platt.
In the Season 2 premiere, Cathy seeks a second opinion, causing a strain on her relationship with Dr. Todd; Sean learns about his sister's cancer while adjusting to life with a pregnant Rebecca; Adam sees a therapist against his will.
Frustrated at not being able to land a spot in the clinical trial of a new treatment by a respected oncologist (guest star Alan Alda), Cathy resorts to supernatural aid; Sean becomes assertive around the house; Adam capitalizes on his classmates' sympathy about his mother's illness.
Cathy and Paul experience frustrations in bed and with the help of their new house mate Andrea, realize they need to set some patient-caregiver limits; Rebecca is put off by the newly medicated Sean; unsatisfied by his physical relationship with Mia, Adam turns to another girl, Emily.
Cathy is intrigued by Lee (Hugh Dancy), a fellow cancer patient she meets on the first day of her clinical trial; Adam's downward spiral continues with a fight at school and refusal to take responsibility for his actions with Emily; Sean is worried that his new house is haunted.
Worried about finances after Paul's layoff, Cathy decides to pawn her jewelry but runs into Lee and has a surprising day with him; Adam gets himself into a compromising situation he can't escape on his own; Sean is ostracized by moms at a local park when he field tests his eco-friendly homemade sling.
Adam's shocking indiscretion threatens Cathy's new job as a swim coach; sparks fly between Andrea and Myk (Boyd Holbrook), a Ukrainian coworker that Paul is mentoring; Sean seeks advice on taking the "next step" with Rebecca.
Paul rises above his jealousy and goes out with Cathy and Lee.
Cathy hosts Thanksgiving dinner at her house but when a secret she's been hiding is revealed, the event takes a disastrous wrong turn; with insurance costs mounting, Paul considers a different means of generating income.
Rebecca deals with the grief over her miscarriage in an unexpected way which leads Cathy to reconnect with old friends; Andrea's relationship with Myk heats up; Adam is taken by surprise when he finally meets the girl he's been chatting with in an online cancer support group.
Cathy helps Lee check a few items off his "bucket list;" Poppy takes Adam to her high school reunion; a distraught Sean takes issue with his new neighbors.
Cathy makes a big decision regarding her family after a fight with Lee and a dinner with Dr. Sherman; Adam goes looking for his missing uncle; Andrea makes an impulsive choice about Myk.
Surprising secrets are revealed about both Myk and Poppy.
To honor her late friend Lee, Cathy (Laura Linney) sets out to run in a New Year's Eve marathon. But as she forges ahead against the advice of her doctor (Reid Scott), Paul's (Oliver Platt) mounting drug problem threatens to derail her plans.