The season premiere finds Johnny still shaken by his Armageddon visions and growing increasingly obsessed with Stillson, whom he's secretly investigating. But another mystery draws him back into the public eye: a test of Johnny's powers by an adversary who is as obsessed with him as Johnny is with Stillson.
Johnny must stop the release of a new anti-wrinkle cream based on his vision of it causing birth defects in the future.
Johnny must stop a series of bad future visions based on the blood donations he receives from six different donors.
After learning Stillson's congressional rival, a long-time incumbent is a war veteran with a dark secret. Johnny ponders whether the truth is more important than Stillson's defeat.
Johnny is kidnapped by three women who take him to a haunted house - each has their own reasons. Penny is romantically obsessed with Johnny and wants to have his baby, Maddy plans on making a "Blair Witch" style Internet event and sell it to Rev. Purdy, and Anita is seemingly obsessed with the mystery of the family who was killed there. While Dana and Sara reluctantly go through the piles of "fan mail" that Johnny receives, Johnny himself unravels the mystery through his visions, and discovers that the young son Nicholas who survived is responsible...and that Anita is that boy, dressed as a woman. With the women's help the police arrive just in time as Anita/Nicholas goes berserk. Johnny manages to restrain her long enough to save his life and Anita is taken away.
Johnny and Rev. Purdy are traveling on a plane when Johnny gets a vision of the plane crashing and eventually determines that the pilot will put the plane into a dive as the engine explodes. He manages to convince the air marshal he's telling the truth but he sees the same vision of destruction compliments of the co-pilot and realizes both men are trying to save the plane. Using his gift Johnny determines the wings are covered with ice due to an instrument malfunction. When the co-pilot is injured Johnny is forced to take his seat and direct the pilot with his visions to take the proper steps to save the plane.
Isolating himself from a demanding public, Johnny gets visions of himself disappearing after making contact with something belonging to a shut-in, Jeffrey Grissom, brought in by his delivery man. Johnny briefly visits him and Grissom talks about wondering where his old home was, then Johnny returns the next day with information to find out Grissom and any trace of him have completely disappeared. Johnny is determined to follow up when he gets a vision of people removing Grissom and the new family moving in. Johnny gets visions of people going through his own home as well and gets close enough to the people following him to get a vision of Grissom in a new home and visits him there. Grissom reveals he is a retired spy kept buried by the U.S. government due to valuable knowledge in his head. The government show up to threaten Johnny and make him "vanish" as well but Johnny trumps them by calling in Dana and the media and having them all follow him and Grissom to his old home . . . where he disappears, escaping his government keepers.
Johnny becomes involved with the mob when his visions lead him to help a mobster whom he sees being gunned down.
A wild old high school friend, Jason, comes to see Johnny seeking a vision of the future as he will be dying of a heart condition. Johnny sees him receiving a successful heart transplant and gives him the good news, but later gets a vision of Jason's sister Kate being killed in a driving accident and becoming the donor. Johnny later gets a vision of the other driver's license plate while Jason takes a turn for the worse, then sees a vision of him and Kate arguing which leads to her going out and getting in the accident. Johnny soon realizes even if he saves Kate and gets Jason a heart through Purdy's connections, someone else who would have received the heart will die. Johnny tracks down the drunk driver, Patrick Hanchin, and confronts him, but sees that even if Johnny stops him from killing Kate, he'll hit a school bus. Trapped in a web of fate where anything he does will make things worse, Johnny ends up provoking a fight with Kate and she dies and Jason lives, as he foresaw . . . but Jason learns from the experience.
Johnny goes the funeral of Bruce's father and somehow gives Bruce visions of what Bruce's life would have been like if he had never met Johnny.
In the aftermath of Kate's death, Johnny's friends stage an intervention to shake him out of his guilt, but as Bruce drives him to Purdy's lakeside resort, he senses a storm is brewing. Now Johnny is forced to try to come to terms with his destiny in order to save the people he loves.
Johnny is recruited to help the CIA track down Osama Bin Laden.
Johnny, Walt, Sarah, and JJ get involved in a search for $2 million on a missing plane.
Johnny tries to prevent a boxer from dying in the ring.
Johnny tries to determine who the mysterious hooded man in his visions are and aid him in the present, while determining more about what the future holds for him personally.