Both disappointed in love, best friends Lizzie (Sally Golan) and Sam (Rebecca Blumhagen) explore the bar scene in search of free drinks and hot men. When Sam learns that her dream guy, Richard (Christopher Newell), is newly single, the girls set their sights on getting him into Sam’s bed. Lizzie finds a “dirty, hot guy” (Topher Mikels) and learns there is no such thing as no-strings-attached sex. Lizzie’s co-worker (Jessie Liebman) tries to pick up Sam.
Sam pursues her dream guy, but faces competition from his hot young neighbor. Can she disprove the notion that nice girls finish last? Lizzie goes undercover to gather evidence in a sexual harassment case, but finds herself getting a little too involved.
Fed up with men who play games, the girls pursue a younger crop of guys with no game. Jason is excited about his date with a woman who doesn’t play games…or so he thinks.
When her neighbor’s moans of ecstasy interfere with Sam’s ability to fill her needs between the sheets with new sex buddy Danny (Russell Brandi), she goes shopping for new hardware to help in the bedroom. Will that be enough to recapture her mojo, or will she have to take more drastic measures?
Lizzie challenges faux Latina vixen Mariposa (Alyse Zwick) to see who can rope in a man by being a bigger bitch; Rule #9, “Always Be the Bigger Bitch.” Sam, utilizing the rule, channels her inner bitch to snag a handsome bike messenger.
After seeing a very ordinary woman with a handsome younger man, Lizzie and Sam go on a mission to find the source of a “magic pussy,” the kind that mesmerizes and hypnotizes guys into subordination.
Sam violates a key depraved girl rule when she starts to fall for Danny, her “friend with benefits.” A sci-fi movie marathon inspires Kaylie (Riley Steele) and Jordan (Cody Deal) to try a little role-playing to spice things up.
When Sam and Lizzie see Kaylie’s boyfriend with another woman at a bar, they decide to help her get even – but first they need evidence. Their spying leads Sam to an old flame. Jason expresses his cynicism about the rules and tries to prevent Kaylie from adopting them.
Sam can’t tell if Devon (Alex Benjamin), her hot new project partner, is gay, which leads the girls to seek counsel from Tyler (Joe Kamara), their gay advice guru. Meanwhile, Lizzie thinks she has found the perfect GBF (gay best friend), but finds herself mistaken when their drunken partying unexpectedly leads to scandalous new territory.
Lizzie and Sam get a surprise visit from Sienna (Whitney Kimball Long), their “Depraved Rules” mentor, who concocts a phony bachelorette party to help them pick up men. When Sienna learns that Sam is interested in Jason, she decides to help Sam get her man by any depraved means necessary.