Monkey See, Doggie Do: Mojo Jojo unleashes a curse that turns everyone into dogs, including the Powerpuff Girls! Luckily, they manage to sniff out a solution and show Mojo Jojo that their bite is worse than his bark.
Mommy Fearest: When Professor Utonium falls head-over-heels in love for the lovely Ima Goodlady, the Girls quickly discover that Ima's not such a good lady after all. She's really the sinister Sedusa, out to keep the Girls grounded for the first time ever while she commits crimes around Townsville, such as making off with the Mayor's jewels.
Insect Inside: Vile villain Roach Coach has a plan to infest Townsville—and eventually the world—with an army of cockroaches! The Girls quickly overcome their squirms to squash Roach Coach's scheme and force him to bug off.
Powerpuff Bluff: Three escaped convicts, repeatedly beaten by the girls, fashion themselves new identities when they find grown-up-sized Powerpuff Girls costumes inside Townsville Jail. Using their pseudo-superhero status, they terrorize Townsville while the Mayor mistakenly sends the real Girls to the slammer.
Octi Evil: The heinous Him toys with Bubbles' mind by speaking to her through Octi, her favorite stuffed animal. Following Octi/Him's instructions, Bubbles provokes a fight between her sisters that prompts the Professor to issue a time-out until the Girls can make amends and make squid-meat out of the giant, Him-controlled Octi.
Geshundfight: The Amoeba Boys' ill-conceived plan to stand in front of the "Keep off the Grass" sign at Townsville Park all night in the rain leaves them with a nasty virus that's nothing to sneeze at. When they infect the Townsville population it's up to the Girls to find the antidote.
Buttercrush: Buttercup becomes smitten with Ace, the leader of the Ganggreen Gang. But when the Gang exploits her infatuation and lures Blossom and Bubbles into danger, Buttercup quickly comes to her sisters' rescue and shows the boys the real meaning of the word "crush."
Fuzzy Logic: Beastly bumpkin Fuzzy Lumpkins goes wild in Townsville and only the Powerpuff Girls—with some help from a flying squirrel—can teach him to respect other people's property.
Boogie Frights: Bubbles must face her fear of the Boogie Man after he blocks out the sun, who intends to have his monster friends partying all the time.
Abracadaver: Al Lusion, the old-time Townsville magician, pulls off his greatest stunt when he comes back from the dead as the zombie Abracadaver. Luckily, Blossom also has a special trick up her sleeve.
Telephonies: The Ganggreen Gang gets hold of the Mayor's hotline to the Powerpuff Girls and makes prank calls, sending the Girls on a wild goose chase all over town. But when it's the notorious villains Mojo Jojo, Fuzzy, and Him that the Gang disturbs, they learn that it's not so fun playing with the big boys.
Tough Love: Everyone in Townsville loves the Powerpuff Girls! But the citizens have a sudden change of heart when Him sends out an evil gas that turns the entire town against their favorite superheroines. The girls' must fight the ones they love to get them back to normal.
Major Competition: There's a new man in town: Major Man, an impossibly perfect superhero who cuts in on the Girls' turf. But in Townsville's time of need, the Girls prove that though they're minors, they're still the major force when it comes to saving the day.
Mr. Mojo's Rising: When Mojo Jojo kidnaps the Professor, it's a blast from the past—a blast of Chemical X, that is. After Mojo Jojo reveals he was once the Professor's beloved assistant the Professor is coerced into giving Mojo the same superpowers as the Girls. But once empowered, the true evolution of this super-villain chimp comes to light, a fact Mojo Jojo will certainly regret (he caused Professor to add Chemical X to the perfect little girl formula, creating the Powerpuff Girls).
Paste Makes Waste: When Buttercup's taunting turns her paste-eating classmate Elmer Sglue into a destructive Paste Monster, she gets out of a sticky situation by doing something against her tough nature—apologizing.
Ice Sore: During a heat wave, Blossom discovers that she has a new power: ice breath. But when she doesn't use her new gift wisely, she gets a chilly reception from her sisters.
Bubblevicious: Bubbles is tired of people dismissing her as more sugar than spice. When she sets out to prove she's hardcore, she takes everyone by surprise, even Mojo Jojo.
The Bare Facts: After Mojo Jojo kidnaps and blindfolds him, the Mayor has to rely on the Girls' very different individual accounts of the crime to figure out exactly what happened. But he's still at a loss to explain why the girls keep giggling at him.
Cat Man Do: Bubbles saves a seemingly innocent little kitty from the clutches of an evil villain. But when the Girls discover it's actually the Cat who is evil, they must save the Professor from becoming the purr-fect victim. Mark Hamill guest stars as the voice of the Cat.
Impeach Fuzz: When Fuzzy Lumpkins throws his hat into the mayoral ring and claims a surprise victory, it's up to the Mayor to wrestle the office (and the Mayor's actual hat) back from him.
Just Another Manic Mojo: After the Powerpuff Girls lose their baseball in Mojo Jojo's window it seems to offer the evil villain the perfect opportunity to destroy the pesky superheroes; if only he can make a useful plan in time.
Mime for a Change: An accidental bleach spill turns Rainbow the Clown into the malevolent Mr. Mime, and he proceeds to turn Townsville black and white and dead all over. The thought of a colorless world has the Girls seeing red, and before he knows it, Mr. Mime's number is up. Features the songs "Rainbow's Theme Song" and "Love Makes The World Go 'Round" by David Smith.
Mojo Jojo creates the ultimate weapons against the Powerpuff Girls—boy equivalents! Enter Brick, Boomer, and Butch: The Rowdyruff Boys. When regular fighting doesn't work against the Boys, the Girls have to use their feminine wiles to seal a victory.
Worried about the Girls' safety, the Professor creates Powerpuff Dynamo, a state-of-the-art giant robot, to help them in battle. When a dynamite duel breaks out between Dynamo and a Giant Fish Balloon Monster, a parody of Godzilla. Little Tokyo, Townsville is the stage of an explosive battle. Also, it's a parody of giant monster films made in Japan, and a spoof of the kaiju film, Godzilla Against Mechagodzilla.