In the not-too-distant future, vampires have come out of the coffin...no longer in need of a human fix. But can a young woman (Anna Paquin) forge a love match with a vampire? HBO presents this drama series based on the books by Charlaine Harris.
Opening with two young adults driving down the road they see a sign selling Tru Blood. After a short confrontation with a vampire they take off.
Next, Sookie Stackhouse,a waitress at a local Bar notices a vampire who walks in. After locking eyes with the vampire she confronts him asking his order. The vampire asks for Tru Blood but due to a lack of vampire activity there isn't any in stock.
Soon Sookie runs out of the bar after the vampire and two people that lure the vampire outside. The two people are found draining the blood from the vampire. The blood is known to enhance the healing process in humans and give a bit of a sex boost.
After Sookie gets saved by Bill she suffers a lot of injuries and Bill tries to save her "the Vampire way". The next day her brother is released from police custody and the bodies of Sookie's attackers are found. Later that day Bill goes to visit Sookie's family and gets a not so friendly welcome.
Bill introduces Sookie to some of his vampire friends while Tara is still troubled by her family and tries to find comfort at LaFayette's.
When one of Merlotte's barmaids is murdered, all fingers point to Jason. And Sookie goes to new territory to find the truth and prove her brother's innocence.
At the Descendants of the Glorious Dead meeting Bill is invited to talk about his life as a Confederate Soldier. Bill then has a question and answer session when one member of the DGD shows Bill a tintype of the Compton family. Sam, Sookie, Tara and Jason are also present at the Descendants of the Glorious Dead meeting. Sookie deals with a loss of someone close to her. Jason notices Tara while he is high on vampire blood.
Sookie seeks solace from her friends after facing a tragedy. Jason suffers from withrawal symptoms. Sam and Tara share a bond in searching a common goal.
Bill gets into action after he learns of Sookies painful past. Jason makes a connection with Amy in Fangtasia searching for V juice. A trio of mysterious red necks come for their old friend Bill seeking justice against vampires.
Sookie braces herself for more tragedy. Tara thinks of a new approach with dealing with her anger by adopting a similar therapy to Lettie Mae. Amy charms a crowd showing a darker side to Jason after the V juice runs out. Bill persuades Sookie into helping Eric using her gifts to catch criminals.
Bill breaks a vampire taboo in protecting Sookie - and must pay a steep price as a result. Jason and Amy break their own taboo by kidnapping a vampire named Eddie in order to harvest his blood. With Lettie Mae apparently cured, a skeptical Tara consults with Miss Jeanette about exorcising her own inner demon. Sookie returns home to yet another horrific tragedy, prompting Bill to enlist an unlikely bodyguard - Sam - to protect her while he's away.
Caught in a compromising position, Sam shares a secret with an incredulous Sookie. Thinking she's been purged of her demon, Tara celebrates with Lettie Mae - but goes off the deep end when she uncovers Miss Jeanette's true intentions. Sookie has a disturbing revelation during Arlene and Rene's engagement party at Merlotte's; Jason and Amy debate what to do with Eddie; and Tara speeds into a bizarre roadside encounter that lands her in jail. At a vampire tribunal to decide his fate, Bill faces a harsh penalty for his offense, but the magister decides on a more creative sentence involving a young human named Jessica.
Bill fulfills the conditions of the tribunal's sentence, although he and Eric find that Jessica doesn't quite turn out as expected. Trying to solve the mystery behind her most recent vision, Sookie heads to a pie shop with Sam and later puts the squeeze on a philandering police officer to get info. Jason helps clean up Amy's mess, worrying about their future, but unable to break away. Tara's anger over Lettie Mae's refusal to bail her out of jail is tempered when Maryann Forrester, a wealthy "social worker," comes to her rescue. Disgusted by the hypocrisy of a vamp-bashing state senator, Lafayette decides to pay him a visit on the campaign trail. In Bill's absence, a vulnerable Sookie finds comfort in Sam. A distraught Jason finds himself in hot water with Bud and Andy, again.
Sookie finds a link to the string of killings in Bon Temps - and ends up in the murderer's crosshairs. Tara decides to make the most of her second chance with Maryann; Jason finds a new calling after anti-vampire zealot Orry visits him in jail; Bill tempts fate during his latest attempt to save Sookie; Sam is perturbed by an encounter with an old acquaintance; Lafayette finds himself in the wrong place at the right time.