What About Brian follows a close-knit group of friends in Los Angeles who are in various stages of relationships. All of the friends have paired off, except for Brian. Brian is living the single life but the only problem is that he is secretly harboring a crush on his best friend's girlfriend.
Brian and Adam make a pact to end their dead-end relationships.
Adam and Dave urge Brian to live out the ultimate single guy's fantasy.
Adam and Marjorie move in together, though Adam is not able to help.
Brian spends the day with his new girlfriend, Lisa B.
Marjorie unwittingly sabotages Brian's new relationship.