Wilfred is a live-action comedy about Ryan, a young man struggling unsuccessfully to make his way in the world until he forms a unique friendship with Wilfred, his neighbor's canine pet. Everyone else sees Wilfred as just a dog, but Ryan sees a crude and somewhat surly, yet irrepressibly brave and honest Australian bloke in a cheap dog suit.
After a failed suicide attempt, Ryan forms a unique connection with his neighbor's dog, Wilfred.
Ryan betrays Wilfred’s trust to gain favor with Jenna, but his deception yields an unexpected secret about her.
Ryan finally learns why Wilfred planted his wallet at the scene of the crime when Spencer comes around seeking vengeance.
Ryan's efforts to reconcile with his sister cause Wilfred to have a shocking experience at doggy day care.
Ryan and Wilfred volunteer at a hospice and discover Wilfred may have a remarkable secret talent.
Wilfred persuades Ryan to help him get rid of Jenna’s boyfriend.
Wilfred's pursuit of a new love interest forces Ryan to swallow his pride - among other things.
When Wilfred learns that Ryan feels responsible for the death of his beloved childhood dog, he goes to otherworldly lengths to help Ryan learn the truth.
Ryan's resentment of his eccentric mother is exacerbated when Wilfred starts treating her like the mum he never had.
Wilfred uses Ryan's unhealthy habit of isolating as a means to rid himself of a neighborhood pest.
Ryan begins to suspect that his friendship with Wilfred may be self-destructive.
Wilfred urges Ryan to sacrifice his newfound happiness for a greater good
Ryan ignores Wilfred's advice, creating an existential crisis for both of them.