Marvel's massive Phase 3 blockbuster Captain America: Civil War has already made a huge splash at the box office in a short amount of time, crossing $300 million domestically and $1 billion mark at the global box office, after two impressive weekends in release. Despite these huge numbers, the superhero adventure couldn't pull off a third straight win in theaters, going up against Sony's The Angry Birds Movie, Universal's Neighbors 2: Sorority Rising and Warner Bros.' The Nice Guys. Captain America: Civil War was bested by Sony's animated adventure The Angry Birds Movie, which earned an estimated $39 million in its first weekend.

Box Office Mojo reports that The Angry Birds Movie opened in 3,932, which is still significantly lower than Captain America's 4,226-theater rollout, but it's the biggest debut Cap and The Avengers have faced thus far. Neighbors 2: Sorority Rising debuted in 3,384 theaters, while The Nice Guys arrived in 2,865 theaters. The Angry Birds has been getting mixed reviews thus far, with a 42% rating on Rotten Tomatoes, down from 56% earlier this week, while its competitors have been faring much better, with Neighbors 2 posting a 61% rating and The Nice Guys scoring an impressive 90% rating on RT. Thanks in part to another sizable drop from Captain America: Civil War, The Angry Birds Movie was able to come out on top with $39 million, pulling in a solid $9,919 per-screen average from 3,932 theaters.

RELATED: Sony Pictures Launches Kids Zone Interactive Family Youtube Channel

Last weekend, Captain America: Civil War dropped 59.5% to earn $72.6 million, which was still more than enough to win its second week in a row. Cap. This weekend, Cap dropped 54.4%, slipping to second place with $33.1 million. The superhero adventure has taken in $347.3 million domestic and $1.05 billion worldwide. Neighbors 2 opened just behind this superhero adventure in third place with $21.7 million, with a decent $6,439 per-screen average from 3,384. This debut is significantly lower than its 2014 predecessor Neighbors, which opened with $49 million en route to a $150.1 million domestic take and $270.6 million worldwide, from just a $28 million budget. Rounding out the top 5 is the final newcomer The Nice Guys in fourth place with a projected $11.2 million, and The Jungle Book with $11 million.

In the 3D animated comedy, The Angry Birds Movie, we'll finally find out why the birds are so angry. The video game adaptation takes us to an island populated entirely by happy, flightless birds - or almost entirely. In this paradise, Red (Jason Sudeikis), a bird with a temper problem, speedy Chuck (Josh Gad), and the volatile Bomb (Danny McBride) have always been outsiders. But when the island is visited by mysterious green piggies, it's up to these unlikely outcasts to figure out what the pigs have planned. The voice cast is rounded out by Bill Hader, Maya Rudolph, Peter Dinklage, Keegan Michael Key, Kate McKinnon, Tony Hale, Ike Barinholtz and Sean Penn in his first animated voice role.

Neighbors 2 reunites fans with Mac (Seth Rogen) and Kelly Radner (Rose Byrne), who have a second baby on the way, and they are ready to make the final move into adulthood: the suburbs. But just as they thought they'd reclaimed the neighborhood and were safe to sell, they learn that the new occupants next door are a sorority even more out of control than Teddy (Zac Efron) and his brothers ever dreamed of being. Tired of their school's sexist, restrictive system, the unorthodox ladies of Kappa Nu have decided to start a house where they can do whatever the hell they want.

When Shelby (Chloe Moretz) and her sisters, Beth (Kiersey Clemons) and Nora (Beanie Feldstein), find the perfect place just off campus, they won't let the fact that it's located on a quiet street stand in their way of parties as epic as the guys throw. Forced to turn to the one ex-neighbor with the skills to bring down the new Greeks next door, the Radners-alongside best friends Jimmy (Ike Barinholtz) and Paula (Carla Gallo)-bring in charismatic Teddy as their secret weapon. If he can infiltrate the sorority and charm his way through it, the thirtysomethings will shutter the Kappas' home.

Set in 1970s Los Angeles, The Nice Guys follows down-on-his-luck private eye Holland March (Ryan Gosling) and hired enforcer Jackson Healy (Russell Crowe), who must work together to solve the case of a missing girl and the seemingly unrelated death of a porn star. During their investigation, they uncover a shocking conspiracy that reaches up to the highest circles of power. The supporting cast is rounded out by Beau Knapp, Keith David and Kim Basinger in this new comedy from director Shane Black (Iron Man 3).

Rounding out the top 10 this weekend will be Money Monster ($7 million), The Darkness ($2.3 million), Zootopia ($1.7 million), The Huntsman: Winter's War ($1.19 million) and Mother's Day ($1.11 million). Also opening in limited release this weekend is Oscilloscope Pictures' Ma ma, which earned $9,466 from just one theater, Sony Pictures Classics' Maggie's Plan, which took in $66,708 from five theaters for a $13,342 per-screen average, and IFC's Weiner, which debuted with an impressive $85,525 from five theaters with a $17,105 per-screen average. No box office data was released for FUNimation Films' Project Itoh - Harmony. We don't know for certain if any of these movies will be expanding to wider releases in the weeks to come, so stay tuned.

Looking ahead to next weekend, 20th Century Fox will debut the highly-anticipated superhero sequel X-Men: Apocalypse, alongside the Disney fairy tale sequel Alice Through the Looking Glass, which will be competing for the Memorial Day weekend crown. Also opening in limited release is Abramorama's As I AM: The Life and Times of DJ AM, Strand's Chevalier, FilmRise's Holy Hell, Adopt Films' The Idol, Magnolia's The Ones Below and Well Go USA's The Wailing. Be sure to check back on Tuesday for next week's predictions, and again on Sunday for the next box office report. Until then, check out the box office estimates for the weekend of May 20.