The French filmmaker says that he intends to devote himself instead to civic projects, including starting a foundation to help youths in France's depressed inner cities.
Besson's 10th and last movie opens in France on Dec. 13 and in the U.S. on January 12.
"They are my 10 little babies," Besson said. "I love them all. I am pleased to have completed this cycle. That is finished."