Betty Thomas is in negotiations to direct Universal's comedy Desperados, which is being developed as a starring vehicle for Isla Fisher.

Wayne McClammy, the director of the Sarah Silverman and Jimmy Kimmel viral videos "I'm F---ing Matt Damon" and "I'm F---ing Ben Affleck," was previously attached, but left due to creative differences.

Written by Ellen Rapoport, Desperados is described as a female-oriented The Hangover. The story is about a woman who sends an indignant email to her new beau, who has gone silent after they have sex, only to discover he's comatose in a Mexican hospital. Panicking, she races south of the border with her friends in tow to intercept the email before he recovers.

No production date has been set.