Chaos spreads throughout the streets of Los Angeles in the first trailer for Big Ass Spider, director Mike Mendez's horror-comedy that debuted at the South By Southwest Film Festival last spring. Greg Grunberg stars as an exterminator, who teams up with a Latino security guard (Lombardo Boyar) to take down the biggest spider on record, a 50-foot tall arachnid that leaves massive amounts of destruction in its wake. Co-starring Lin Shaye, Ray Wise, Clare Kramer and genre icon Lloyd Kaufman, Big Ass Spider debuts in theaters and VOD platforms October 18. In addition, you can also take a look at the poster that debuted earlier this year.