After two straight weeks atop the box office, Marvel's Ant-Man will surely be dethroned this weekend, with the arrival of two new releases, Paramount's Mission: Impossible Rogue Nation and New Line Cinema's Vacation. Mission: Impossible Rogue Nation will easily take the top spot, somewhere in the low $50 million range, in its first week in theaters. The fifth installment of the lucrative Mission: Impossible franchise is heading into theaters with a strong wave of critical buzz, with a 93% "Fresh" rating on Rotten Tomatoes. Even though Vacation debuted on Wednesday, and the reviews haven't been favorable (25% "Rotten" rating), it should still easily take the second place spot.

Mission: Impossible Rogue Nation opens in 3,956 theaters today, with action icon Tom Cruise reprising his role as Ethan Hunt for the fifth time. He is joined by stars of 2011's Mission: Impossible Ghost Protocol, Jeremy Renner, Simon Pegg and Ving Rhames, along with a slew of new cast members such as Rebecca Ferguson, Sean Harris, Simon McBurney, Jingchu Zhang and Alec Baldwin. Some project this action-thriller won't surpass the $50 million mark this weekend, but with the incredibly positive reviews, it should have no trouble taking the top spot with over $50 million. It has already taken in $4 million from Thursday night preview screenings, according to Deadline.

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Vacation opened in 3,411 theaters on Wednesday, taking in just $3.8 million on its first day. The comedy is R-rated, which means kids on their summer break won't be able to see it. But the numbers should steadily improve throughout the weekend as adults seeking R-rated summer fun seek to close out their long work week. Ed Helms stars as the grown-up Rusty Griswold, who takes his family on their first ever road trip to Walley World, replicating his own trip to the amusement park as a child. Chevy Chase and Beverly D'Angelo return as Rusty's parents, Clark and Ellen Griswold, alongside Christina Applegate, Chris Hemsworth, Leslie Mann and Charlie Day. With this star power in tow, Vacation should have no trouble cracking $20 million in its opening weekend.

The rest of the top 5 will be filled out by holdovers, with Ant-Man dropping to third place, Minions taking fourth place, and Trainwreck sliding into fifth place. The top 10 will be rounded out by Pixels, Southpaw, Paper Towns, Inside Out and Jurassic World. There is a chance that the indie drama Mr. Holmes cracks the top 10 this weekend, since it expands from 215 theaters to 901 theaters. Mr. Holmes took ninth place last weekend with $2.8 million, but it remains to be seen how audiences in these expanded markets will react to the film. Also opening in limited release is A Lego Brickumentary and The End of the Tour, starring Jesse Eisenberg and Jason Segel.

Looking ahead to next weekend, there will be four new movies opening in wide release vying for your late-summer dollars, 20th Century Fox's Fantastic Four reboot, STX Entertaiment's indie thriller The Gift, TriStar's Ricki and the Flash and Lionsgate's animated comedy Shaun the Sheep. Opening in limited release is Focus Features' Cop Car, directed by the new Spider-Man filmmaker Jon Watts and starring Kevin Bacon, A24's Dark Places starring Charlize Theron and Chloe Moretz, and The Diary of a Teenage Girl starring Kristen Wiig. Check back on Sunday for this weekend's box office results, but until then, take a look at our projected top 10.