After a failed attempt at continuing what could be a promising franchise with the long-delayed Cabin Fever 2: Spring Fever, the Indomina Group is moving forward with a prequel to Eli Roth's original 2003 thriller Cabin Fever.

Cabin Fever: Patient Zero will be directed by comic book artist-turned-director Kaare Andrews, best known for his creepy 2010 horror outing Altitude. While that film took place in the sky on an airplane, this latest entry in the Cabin Fever franchise will take place on a boat, as a crew struggles to avoid being consumed by the infamous flesh eating virus after they crash into a desolate island research facility.

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Jake Wade Wall, who was responsible for writing the moderately received The Hitcher remake, is on board as screenwriter. He is setting Cabin Fever: Patient Zero up to segue into a fourth sequel entitled Cabin Fever: Outbreak.

Cabin Fever: Outbreak will be written by Debra Sullivan and Adam Marcus. It follows a doctor on a Caribbean island that tries to contain the virus in the aftermath following Cabin Fever: Patient Zero. It is not known if Kaare Andrews will direct both films.