Carib Chief Charles Williams said talks with Disney's producers revealed there was "a strong element of cannibalism in the script which cannot be removed".
The Caribbean island's government said Disney planned to film in Dominica.
The Caribs have long denied their ancestors practised cannibalism. Disney was unavailable for comment.
"Our ancestors stood up against early European conquerors and because they stood up...we were labelled savages and cannibals up to today," said Mr Williams.
About 3,000 Caribs live on the island of Dominica.
"This cannot be perpetuated in movies."
Shooting on the sequel is expected to begin in April, with hundreds of Dominicans applying to be extras in the movie.
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