The 2000s was an epic time in animated television that introduced audiences to celebrated cartoon classics, with many debuting on Cartoon Network. The fan-favorite channel is no stranger to creating popular, cutting-edge programs that to this day remain beloved gems, with shows like Teen Titans, The Grim Adventures of Billy and Mandy, and Ben 10 taking viewers by storm. Since its groundbreaking launch in 1992, Cartoon Network has continued to be a dominant force in cable television, reaching 94 million households as of 2021.
Audiences fell in love with an array of colorful and memorable characters on the channel, from the perpetually scared pooch in the surprisingly creepy Courage the Cowardly Dog to enchanting, made-up pals in Foster’s Home For Imaginary Friends. With such an impressive selection of content, Cartoon Network was undeniably the place to go for all your animated series needs. These are the best Cartoon Network shows of the 2000s.
Updated on August 9th, 2023 by Rachel Johnson: This article has been updated with additional content to keep the discussion fresh and relevant with even more information and new entries.
15 Chowder
Chronicling the many hijinks the titular food aficionado finds himself in as he works as an apprentice at Chef Mung Daal's delicious catering company, 2007's Chowder features the rabbit-bear-cat hybrid as he strives to learn more about cooking while oftentimes causing chaos in the kitchen due to his insatiable appetite and his unintentional carelessness.
Series creator C.H. Greenblatt loosely based the comedy's premise on The Sword in the Stone, with a respected master chef teaching his young star pupil how to perfect the art of making food. During its three-season run, Chowder managed to delight audiences with its quirky and lovable lead character and won a Primetime Emmy Award for Outstanding Individual Achievement in Animation. The program was canceled by the network as they did not believe it fits in with their new demographic, wanting to shift their focus and target viewers to older boys.
14 My Gym Partner's a Monkey
The underrated and delightfully zany 2005 slapstick comedy My Gym Partner's a Monkey follows the misadventures of 12-year-old middle school student Adam Lyon as he is mistakenly transferred to a new school for anthropomorphic zoo animals after a mix-up occurs due to the misspelling of his last name. Adam decides to make the most out of his bizarre situation and ends up befriending the eccentric, trouble-making spider monkey Jake, with the duo getting into all kinds of hilarious situations while attending Charles Darwin Middle School.
My Gym Partner's a Monkey was a ratings hit for Cartoon Network, topping the Fridays block ratings and attracting millions of weekly viewers; its impressive premiere episode was seen by 1.2 million people. Lauded for its unique and out-of-the-box premise, the series aired for four seasons and went on to spawn a 2007 television film as part of their third season special.
13 Totally Spies!
Following the lives of teenage super agents Alex, Clover, and Sam as they work undercover in Beverly Hills while dealing with the growing pains of going to high school, the 2001 spy-fi show Totally Spies! chronicles the trio's misadventures fighting conniving bad guys and looking stylish while they do it. Series co-creator David Michel wanted to incorporate fictional Japanese influences and was inspired by the '90s hit Clueless and the thrilling James Bond format.
The girl-power program initially ran for five seasons before being revived for a sixth in 2013, with a prequel theatrical film being released in 2009; an upcoming seventh season is scheduled for release sometime in 2024. With the series seeing several viral tweets over the years, excitement for this new season is certainly there. The viewership and critic reviews will show if these fans tune in to revisit their favorite three girls and get into all kinds of over-the-top adventures.
12 Camp Lazlo!
Centering on the offbeat and cheerful anthropomorphic spider monkey Lazlo as he attends the poorly looked after Camp Kidney with his elephant and rhinoceros pals Raj and Clam, 2005's Camp Lazlo! depicts the trio's wild shenanigans as they continuously challenge the fun-loathing, cranky Scoutmaster Lumpus and set out to have an exciting summer. The show's wholesome and inviting setting was deliberately designed to invoke nostalgia and comfort viewers, with creator Joe Murray wanting to give it a retro feel that featured cartoon designs of the '50s and '60s.
Murray wanted the humor of the series to mirror that of Rocko's Modern Life (which he also created), and he felt inspired to come up with the comedy due to his love of his own days at summer camp and the happiness it brought him. Camp Lazlo! ran for five seasons on the network and during its spectacular run received an impressive three Primetime Emmys and three Pulcinella Awards.
11 Samurai Jack
2001 animated action-adventure Samurai Jack centers on the titular, katana-wielding prince as he is sent into a dangerous dystopian future by a nefarious shape-shifting demon determined to take over his land. It is up to the powerful warrior to tackle a variety of formidable foes on his quest to return to his own time, culminating in a final showdown between Jack and the evil ruler Aku.
Created by Genndy Tartakovsky (Dexter's Laboratory), the cartoon was based on his interest in both the bushido code and samurai culture.
Tartakovsky shot the series to capture the cinematography of the 1970s and also embody classics like Spartacus and Lawrence of Arabia. Samurai Jack ran for five seasons including a short-lived 2017 revival. Future plans for this intellectual property are unknown, and a lot of fans might be happy about that. With the rise of live-action adaptations, however, it is not impossible that Samurai Jack could be one of the franchises next in line; especially with how creative it is from a visual and narrative standpoint.
10 Total Drama
Competitive reality shows like Survivor, Big Brother, and The Amazing Race ran supreme all throughout the 2000s, so it is only natural for a popular genre to be satirized during that time period as well. Total Drama combined the aspects of these shows that were easy to make fun of, and turned them into something that was enjoyable for teenagers at the time of its debut in 2007. The show was known for its diverse cast, the themed seasons, and its unique format; all of which contributed to its success and memorability.
While some controversial scenes may not have aged well as the years went by, Total Drama cannot be denied its spot as a Cartoon Network staple. So much so, that a total reboot of the series is now streaming on HBO Max with a brand-new cast, and new challenges at the first season's iconic camp setting. The future of Total Drama's revival is unknown, and likely dependent on the new season's reception, but its overall longevity suggests that it is here to stay, and will continue to reinvent itself to remain relevant to the new generation of fans.
9 Justice League
The world's most powerful heroes joined forces once again to keep humanity safe from nefarious threats in the 2001 action animated series Justice League, with some of DC's most cherished superheroes like Wonder Woman, Batman, and Superman starring in the spellbinding Cartoon Network hit. The series featured an A-list cast of some of the industry's best vocal performers like Kevin Conroy, George Newbern, and Susan Eisenberg.
The show delved into the fan-favorite characters' backstories and origins as they were all brought together to assemble and form the most capable team of all time. Justice League is widely regarded as one of the best animated shows of all time, dazzling both audiences and critics with its stunning visuals, superb performances, and engrossing storylines. Its second season has been deemed arguably the greatest season of the whole DC Animated Universe.
8 The Powerpuff Girls
While it debuted in the very late 90s in 1998, most of the Powerpuff Girls ran through the early-to-mid 2000s. The lore of the series revolves around Professor Utonium, and his scientific endeavor to create "perfect little girls". As shown in the show's intro, something known as Chemical X in the fictional world was accidentally added to the mix, granting them super-powered abilities. Their name (as a group) comes from the shape of their heads, and their similarity to a powder puff, a makeup-applying tool used to apply powder to one's face.
The series shows the three girls (left to right) Buttercup, Blossom, and Bubbles fighting villains that threaten their city, while navigating all the complex issues that girls their age have to go through on a daily basis. This balance between having to be the hero, while also having to take care of personal matters struck a chord with preteen and teenage girls across the world, which is why this cartoon is one of the more recognized. Attempts to revive the show have not always been successful, but the critical acclaim of the original series goes to show that a return would be welcomed.
7 Ben 10
When 10-year-old Ben Tennyson discovers a mysterious watch-like device while on a camping trip with his grandpa and cousin, the adolescent finds himself with the ability to shift into wondrous alien creatures in the 2005 series Ben 10. Ben is given unique powers and spectacular skills as he is able to transform into ten vastly-different aliens, using his newfound abilities to protect his family and Earth from evil outside forces.
Famed, widely loved voice actress Tara Strong offered her talents for the hit program, tackling the iconic role of Ben in addition to fellow beloved characters like Benwolf, Upgrade, and Buzzshock. Ben 10 had a very successful four-season run and led to the acclaimed follow-up spin-offs Ben 10: Alien Force, and a 2016 reboot. Much debate surrounds which iteration was the best, but each has its own sect in the fanbase that would be willing to go to war in its defense.
6 Teen Titans
Adapted from the titular DC Comics superhero team, the 2003 anime-inspired animated series Teen Titans follows the crime-fighting adolescents consisting of Robin, Starfire, Raven, Cyborg, and Beast Boy as they protect Jump City from dangerous foes like Slade, Brother Blood, and Trigon. Co-creator Glen Murakami wanted the characters to maintain their superhero identities the whole time throughout the program's run.
The overwhelming popularity and fanbase of Teen Titans led to an original five-season run and a TV movie, and spawned the follow-up series Teen Titans Go! The cartoon was nominated for numerous Annie Awards and TVLine included it on its list of best animated series themes of all time, with many praising its catchy and memorable intro. While it faces some criticisms over some choices made when it came to adapting the characters, the series remains one of the prime Cartoon Network hits of the 2000s.
5 Codename: Kids Next Door
Chronicling the entertaining adventures of a group of unique 10-year-olds as they battle to fight crime against adults in their secret espionage tree house, 2002's Codename: Kids Next Door is a Cartoon Network gem that was a ratings hit for the channel.
Centering on the diverse, code-named children Nigel, Hoagie, Kuki, Wallabee, and Abigail, each episode revolves around the group tackling crimes committed by adults using advanced technology, taking on everything from homework to dentist appointments. The series went on to produce 6 seasons and two television films as well as an unexpected, but well-received cross-over episode with The Grim Adventures of Billy & Mandy.
4 Foster's Home For Imaginary Friends
Revered creator Craig McCracken (The Powerpuff Girls) once again hit cartoon gold when he introduced audiences everywhere to Foster's Home For Imaginary Friends, with the animated series taking place in a wondrous world where children's imaginary pals can take physical form and actually exist.
With memorable and charming characters like Bloo, Eduardo, and Wilt, the program focuses on the bright 8-year-old Mac and his struggles with growing older and fears of leaving his imaginary friends behind. McCracken developed the six-season show to have an eccentric style that evoked "that period of late 60s psychedelia when Victorian stylings were coming into trippy poster designs" and wanted it to be a family-friendly program all ages could enjoy.
3 The Grim Adventures of Billy and Mandy
After losing a wager with the dippy boy Billy and cynical girl Mandy, the Grim Reaper is forced to become the duo's best friend and servant in The Grim Adventures of Billy and Mandy, with the series depicting their many misadventures involving both the supernatural and life's everyday struggles.
Despite being initially miserable about his servitude to the scheming kids, Grim eventually begins to grow fond of Billy and Mandy (albeit just a little), and their love-hate relationship is hilariously prevalent throughout its six seasons. The program was a critical and commercial hit, winning two Emmy Awards and an Annie Award while also leading to three television movies.
2 Ed, Edd, n Eddy
Fewer animated shows proved as popular and enduring as the 2000s cult classic Ed, Edd, n Eddy, which focuses on the preteen trio of boys as they concoct schemes and scams in their suburban cul-de-sac in hopes of making money and buying their beloved jawbreakers.
Adult cartoonist Danny Antonucci was dared to try and produce a kid-friendly program, designing the eponymous characters while working on a commercial; he based their personalities on his own personal traits and drew inspiration from his two sons and children he grew up with. Ed, Edd, n Eddy was undeniably one of Cartoon Network's most successful original series and attracted a massive audience of 31 million households during its five seasons, becoming a celebrated staple for viewers of all ages.
1 Courage the Cowardly Dog
Praised for its creepy, foreboding atmosphere and delightfully dark humor, the beloved, wonderfully bizarre Cartoon Network comedy horror series Courage the Cowardly Dog may have premiered at the end of 1999 but became a massive 2000s hit despite its seemingly short four-season tenure. Following the easily frightened yet loving titular pooch as he lives on a remote farm in a town called Nowhere with the nurturing Muriel and mean-spirited Eustace, the classic show depicts the many terrifying foes and evil forces Courage is constantly squaring off against.
Series creator John R. Dilworth turned his Oscar-nominated animated short The Chicken from Outer Space into a full-length show for the network, having previously worked on lauded shows like Doug and Rugrats. The spine-tingling series went on to win both an Annie and Golden Reel Award, and was described by the online magazine PopMatters as "a fascinating and textured mixture of cartoon and horror-movie conventions, and a joy to watch."