Grammy Award-winning and multi-platinum recording artist and actor Dave Matthews, founder of the Dave Matthews Band, will guest-star on an upcoming episode of House. Matthews will play "Patrick," a savant and virtuoso pianist who suffered a severe neurological impairment as the result of an accident when he was a child. Kurtwood Smith (That '70s Show) will guest-star as a former physician and Patrick's father, who must make a potentially life-altering decision about his son's treatment. The episode is directed by House executive producer Katie Jacobs and is tentatively scheduled to air in March. House airs Tuesdays (9:00-10:00 PM ET/PT) on FOX.

After Patrick is admitted to Princeton-Plainsboro Hospital with a rare movement disorder, his case attracts the attention of Dr. House (Hugh Laurie). House is intrigued as to why Patrick, who was a healthy 10-year-old at the time of his accident with no prior musical training, could suddenly play the piano flawlessly after suffering a severe injury. While trying to deduce the origin of the brain rewiring responsible for Patrick's mysterious gift of music, House and his team must stop the deadly cerebral bleeding that is now threatening his life.

House is the No. 1 drama and the No.1 entertainment program on FOX and ranks No. 1 in the Tuesday 9:00 PM hour among all key demos, significantly outperforming its closest competitor in Adults 18-49 and Adults 18-34. House ranks in the Top 10 programs of the season among Adults 18-49, Adults 18-34, Teens and all key male and female demos.

Since their formation in 1990, Dave Matthews Band has sold more than 35 million albums worldwide to date and over 14 million concert tickets since 1992. In 2003, Matthews released his first solo album, "Some Devil." The album's first single, "Gravedigger," won Matthews a Grammy Award for Best Male Rock Vocal Performance in 2004. Dave Matthews Band recently released their first retrospective, "The Best of What's Around, Vol. 1," a unique double disc set representing the band's versatile strengths on stage and in the studio. The band is currently in the studio working on their forthcoming album, which will be released this summer.

This year, Matthews will star in the independent family drama film Lake City, playing a villain opposite Sissy Spacek and Troy Garity. His other acting credits include the role of "Otis" in the film Because of Winn-Dixie, opposite Jeff Daniels.

Kurtwood Smith spent eight seasons playing the hugely popular Red Foreman on That '70s Show and is currently shooting the cable pilot Insatiable opposite Andie MacDowell. His television credits also include Malcolm in the Middle, The X-Files, 3rd Rock From the Sun, Star Trek: Voyager, Deep Space Nine, Picket Fences and, most recently, as a famous FBI criminal profiler on Medium. He was seen in the telefilms A Bright Shining Lie, The Magnificent Seven, While Justice Sleeps, Doorways, The Christmas Gift and The Nightmare Years, for which he received a CableACE Award nomination for Best Supporting Actor.

Smith has been featured in such successful films as Girl, Interrupted, Dead Poets Society, Deep Impact, Citizen Ruth, A Time to Kill, Broken Arrow, Under Siege 2: Dark Territory, To Die For, Boxing Helena, Fortress, The Crush, True Believer and in the memorable role of "Clarence Boddicker" in RoboCop, among others. Smith also starred in the short film "12:01 P.M.," about a man caught in a time warp; it was nominated for an Oscar in the Best Short Film category.

Dont't forget to also check out: House: Season One [3 Discs]