The X-Files 2: While doing the promotion rounds for the upcoming X-Files: Resist or Serve video game, David Duchovny talked to Razor Magazine about the game as well as the proposed X-Files movie sequel:

We're also working to put together the next X-Files movie. I'd imagine we'd get into shooting in the next year or so, depending on when the script is written.
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CLICK HERE for the entire article which includes Duchovny's review of the video game!

Dont't forget to also check out: The X-Files: I Want to Believe