David Murray's name was originally being bandied about for the role of Destro in G.I. Joe: Rise of Cobra before the role ultimately went to former Doctor Who Christopher Eccelston. However, according to Hisstank.com Murray will still be playing Destro in the film - just not the Destro of the modern era.

Casting information acquired at the European Cinema Expo reveals that Murray will play the first Destro in the film in a flashback sequence. Murray's arc will come to explain how the Destro clan ended up being associated with the face-covering metal mask the character is known for.

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G.I. Joe: Rise of Cobra is currently filming and is scheduled for an August 7, 2009 release. The film stars Ray Parks, Sienna Miller, Rachel Nichols, Said Taghmaoui, Adewale Akinnuoye-Agbaje, Marlon Wayans, Channing Tatum, Dennis Quiad, Joseph Gordon-Levitt, Arnold Vosloo, Karolina Isela Kurkov, Byung Hun Lee and Christopher Eccleston.