According to The Hollywood Reporter, Gibson will play a fanatical animal-rights activist who frees illegally imported exotic snakes from pet stores, sending them into the Everglades, where they grow to mega sizes. Tiffany will play an overzealous park ranger who uses dangerous methods to save endangered alligators.
In the script, the pair brawl at a party, then take matters outside into the swamp.
Both singers previously have been cast in Syfy originals but never have appeared together.
Mary Lambert will direct, marking the first time a woman has helmed a Syfy creature feature. Naomi Selfman will pen the script. The project will begin shooting this month and air next year.