3000 Degrees: Ed Harris and Woody Harrelson are the first to go into the fire.

The actors are set to star in 3000 Degrees, a fact-based drama about a fire that turned a century-old storage building in Worcester, Mass., into a cinderbox and claimed the lives of six firefighters in December 1999.

The drama is an adaptation of Sean Flynn's book "3000 Degrees: The True Story of a Deadly Fire and the Men Who Fought It." The book grew out of Flynn's July 2000 Esquire article on the subject. Scott Silver wrote the screenplay.

Billy Crudup also is in negotiations to join the Warner Bros. project, which Danny Boyle (28 Days Later) will direct.

Harris next stars in Winter Passing and Empire Falls for HBO. He is a four-time Oscar nominee, having landed mentions for best supporting actor for Apollo 13, The Truman Show and The Hours and a best actor nomination for Pollock.

Harrelson just wrapped After The Sunset and appeared in Anger Management. He starred in The People vs. Larry Flynt and Natural Born Killers, earning an Oscar nomination for his lead role as the famed porn king in the former movie.

Crudup appeared in last year's Big Fish. His other credits include Almost Famous, Waking the Dead and Without Limits.