Grey's Anatomy's Eric Dane and Patrick Dempsey have signed on for the ensemble comedy Valentine's Day, which Garry Marshall is directing for New Line. They join Julia Roberts, Emma Roberts, Anne Hathaway, Jessica Alba, Jessica Biel, Jennifer Garner, Shirley MacLaine, Bradley Cooper, Ashton Kutcher, Topher Grace and Hector Elizondo.

According to Variety, Dane will play a quarterback struggling over the decision of whether to retire. Dempsey will play a married obstetrician dating Garner's character on the sly, with her unaware of his status.

Valentine's Day follows five interconnecting stories on Valentine's Day in Los Angeles. Katherine Fugate wrote the first script, and Abby Kohn and Marc Silverstein teamed for the most recent.

Production is set to begin this week.