Based on the novel My Sister's Keeper by Jodi Picoult, Nick Cassavetes latest drama is a heartbreaking look at a young girl with leukemia and the relationship she shares with her sister. Anna is not sick, but she might as well be. By age thirteen, she has undergone countless surgeries, transfusions, and shots so that her older sister, Kate, can somehow fight the disease that has plagued her since childhood. The product of preimplantation genetic diagnosis, Anna was conceived as a bone marrow match for Kate, a life and a role that she has never challenged until now. Like most teenagers, Anna is beginning to question who she truly is. But unlike most teenagers, she has always been defined in terms of her sister and so Anna makes a decision that for most would be unthinkable. A decision that will tear her family apart and have perhaps fatal consequences for the sister she loves. We recently met up with both Cameron Diaz and Sofia Vassilieva, stars of this emotionally devastating drama, to chat about their experiences on set. To watch our exclusive interview, click on the video clip below:

My Sister's Keeper opens on June 26th, 2009.