Jennifer Connelly, Kevin Connolly, Bradley Cooper, Justin Long and Ginnifer Goodwin are in negotiations to star in He's Just Not That Into You for New Line Cinema, according to The Hollywood Reporter. Drew Barrymore is set to star in the ensemble comedy and is also producing via her Flower Films production company with partner Nancy Juvonen.

Ken Kwapis is directing He's Just Not That Into You, which is based on the best-selling book that is a social commentary about modern-day relationships and how men and women often misconstrue the intentions of the opposite sex. The book was written by Greg Behrendt and Liz Tuccillo, who worked together on Sex and the City as a consultant and writer, respectively. Abby Kohn and Marc Silverstein, who wrote the Barrymore starrer Never Been Kissed, wrote the adaptation.

The Baltimore-set movie of interconnecting story arcs deals with the challenges of reading or misreading human behavior. Jennifer Connelly plays a woman stuck in a tired marriage with Cooper's character. Kevin Connolly, meanwhile, is a man pining after a woman, still not cast, who is having an affair with Cooper.

Goodwin is a young woman obsessed with Kevin Connolly's character who tries to set up accidental meetings with him only to run across his friend, played by Long, who takes her on as a My Fair Lady experiment.

Barrymore plays a woman perpetually confused by dating, now more than ever in a culture that is more obsessed with technology than actual human contact.

Production is due to start early September in Los Angeles.